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1.
Chest ; 109(3): 845-6, 1996 Mar.
Article in English | MEDLINE | ID: mdl-8617102

ABSTRACT

A 29-year-old woman presenting with an ectopic adrenocorticotropic hormone syndrome and a nodule of the upper lobe of the left lung was explored by indium 111 (111In) octreotide scintigraphy. This showed a pathologic uptake by the nodule. Treatment with octreotide resulted in the rapid control of hypercortisolism prior to surgery.


Subject(s)
ACTH Syndrome, Ectopic/drug therapy , Antineoplastic Agents, Hormonal/therapeutic use , Bronchial Neoplasms/drug therapy , Bronchial Neoplasms/metabolism , Carcinoid Tumor/drug therapy , Carcinoid Tumor/metabolism , Octreotide/therapeutic use , ACTH Syndrome, Ectopic/diagnostic imaging , Adult , Bronchial Neoplasms/diagnostic imaging , Carcinoid Tumor/diagnostic imaging , Female , Humans , Indium Radioisotopes , Radionuclide Imaging , Treatment Outcome
10.
Diabete Metab ; 16(1): 37-41, 1990.
Article in French | MEDLINE | ID: mdl-2332095

ABSTRACT

8 healthy subjects have eaten in the morning, after an overnight fast, in two separated occasions and in a randomised order 50 gr of CHO as pasta or couscous. Blood glucose after pasta ingestion was lower at 30 mn (p less than 0.05) at 45 mn (p less than 0.01) and at 60 mn (p less than 0.05). Area under the curve after pasta was significantly reduced (p less than 0.01). In a second time 6 IDDM patients have eaten in a randomised order a meal made of pasta with tomato sauce (P = 11%, F = 30%, G = 59%) or couscous with vegetables and sauce (P = 10%, F = 37%, G = 53%). Blood glucose after the pasta was lower than couscous at 90 mn (p less than 0.05) the area under the curve after the pasta ingestion was reduced of 38% but did'nt reach significance. In conclusion couscous has a higher glycemic effect than pasta although it has a similar composition. This phenomenon is still observed when the cereal products are mixed with other foods and ingested by IDDM patients.


Subject(s)
Blood Glucose/metabolism , Diabetes Mellitus, Type 1/blood , Dietary Carbohydrates , Edible Grain , Energy Intake , Humans , Random Allocation , Reference Values
11.
JAMA ; 262(3): 352, 1989 Jul 21.
Article in English | MEDLINE | ID: mdl-2739034
12.
Ann Pediatr (Paris) ; 36(4): 279-82, 1989 Apr.
Article in French | MEDLINE | ID: mdl-2662879

ABSTRACT

We report two cases of a syndrome combining Addison disease, cardial achalasia, and alacrimation in two girls aged 4 and 5 1/2 years. Moreover, these patients exhibited some unusual features: both also had mineralocorticoid deficiency, and one had loss of tongue papillae and absence of the pupillary reflex. This syndrome is infrequent. Etiology is unknown. Pathophysiology is under debate; autonomic nervous system dysfunction seems likely. We have analyzed the features of this syndrome on the basis of our two observations and the 15 previously reported cases.


Subject(s)
Addison Disease/complications , Dry Eye Syndromes/complications , Esophageal Achalasia/complications , Child, Preschool , Female , Humans , Syndrome
14.
Rev Mal Respir ; 6(5): 465-7, 1989.
Article in French | MEDLINE | ID: mdl-2690211

ABSTRACT

We report a case of a 64 year old male who was a chronic smoker who presented with walking troubles and an acute severe deterioration in his general health. Examination revealed a polyradiculoneuritis. A search for a cause revealed a poorly differentiated epidermoid carcinoma of the lung. Thus the final diagnosis was that of paraneoplastic P.R.N.


Subject(s)
Bronchial Neoplasms/complications , Carcinoma, Squamous Cell/complications , Polyradiculoneuropathy/etiology , Bronchial Neoplasms/diagnostic imaging , Carcinoma, Squamous Cell/diagnostic imaging , Humans , Male , Middle Aged , Radiography
15.
Dis Markers ; 7(1): 43-7, 1989.
Article in English | MEDLINE | ID: mdl-2714046

ABSTRACT

The frequency of HLA A, B, and DR antigens as well as the Bf and C4 allotypes have been investigated in insulin-dependent diabetes mellitus (IDDM) and compared to that of healthy controls in the Tunisian population. An increase of A30, DR3, DR4, BfF1, C4Ao, and C4Bo and decrease of B40, DR2, DR5, and DR6 were found in diabetics when compared to the value observed in controls. The strongest association was noticed with HLA DR3 and DR4. Heterozygotes DR3 DR4 were very frequent in diabetics: 24.2 per cent versus 3.6 per cent in controls (relative risk 7.72). The protective role of DR2 and DR5 antigens were also confirmed. No supratypes of HLA, Bf, and C4 alleles associated with IDDM have been observed among these Tunisian patients.


Subject(s)
Diabetes Mellitus, Type 1/immunology , HLA-A Antigens/analysis , HLA-B Antigens/analysis , HLA-DR Antigens/analysis , Adolescent , Adult , Biomarkers , Child , HLA-C Antigens/analysis , Humans , Phenotype , Tunisia
16.
Article in French | MEDLINE | ID: mdl-2693519

ABSTRACT

The relationship between sex hormones and the skin is increasingly considered to be very important. The skin has appropriately been called "A peripheral endocrine gland". In this review some aspects of the cutaneous metabolism of oestrogens, progestogens and particularly androgens are analyzed. Production of skin collagen is markedly enhanced by oestrogens. Progestogens with strong androgenic activity and especially androgens have a powerful stimulating action on all skin elements particularly the epidermis and the dermis the sebaceous glands and the hair. The skin manifestations of hyperandrogenism and disturbances of reproductive functions such as anovulation, oligoamenorrhoea and polycystic ovarian disease are usually the consequences of three main aetiopathogenic factors: the first is an abnormality of GnRH pulsatility related to central nervous system dysfunction and seemingly mediated by an increase in beta Endorphin, possibly related to some extent to changes in body weight and hyperinsulinism. The second aetiopathogenic approach is hyperaestronaemia secondary to obesity. Finally adrenal hyperandrogenism caused by different types of congenital adrenal hyperplasia or by increased sensitivity to ACTH may be implicated in these various clinical manifestations.


Subject(s)
Amenorrhea/etiology , Anovulation/etiology , Endocrine System Diseases/etiology , Gonadal Steroid Hormones/metabolism , Polycystic Ovary Syndrome/etiology , Skin/metabolism , Androgens/metabolism , Androgens/physiology , Estrogens/metabolism , Female , Humans , Progesterone/metabolism , Skin/physiopathology , Skin Diseases/etiology
17.
Ann Biol Clin (Paris) ; 47(1): 23-8, 1989.
Article in French | MEDLINE | ID: mdl-2648900

ABSTRACT

There is no doubt that the autoimmune process in human disease depends on genetic factors. Varying associations were noticed between HLA DR and autoimmune disorders. The frequency of HLA-A-B and DR antigens as well as the Bf and C4 allotypes have been investigated in insulinodependant diabetes mellitus (IDDM) and compared to that of healthy controls in Tunisian population. An increase of A30, DR3, DR4, BfF1, C4AQ0 and C4BQ0 and decrease of B40, DR2, DR5 and DR6 were found in diabetes when compared to the value observation controls. The strongest association was noticed with HLA, DR3 and DR4. The prospective role of DR2 and DR5 antigens were also confirmed. Examination of HLA, Bf and C4 alleles. Two supratypes associated with IDDM have been observed among the Tunisian patients.


Subject(s)
Diabetes Mellitus, Type 1/genetics , HLA Antigens/genetics , Adolescent , Adult , Child , Child, Preschool , HLA Antigens/analysis , Heterozygote , Humans , Phenotype , Polymorphism, Genetic , Tunisia
20.
Tunis Med ; 65(12): 739-44, 1987 Dec.
Article in French | MEDLINE | ID: mdl-3332954

ABSTRACT

PIP: Sex hormones play an important role in the control of glucose metabolism and insulin. Decreased glucose tolerance observed at the end of pregnancy in most cases remains within normal limits. Pregnancy has an important effect on the islets of Langerhans and on the growth of beta cellules. At the end of pregnancy, assimilation of glucose and triglycerides by maternal tissues is slowed and transfer to the fetus is favored. Hyperinsulinism persists but insulin resistance at the level of maternal tissue becomes very strong and the number of receptors declines. This late pregnancy insulin resistance has not been satisfactorily explained. The declining number of receptors may be a mechanism, or the "antiinsulin" pregnancy hormones which includes estrogens and progesterone may play a major role. Although other mechanisms have been proposed to explain the antiinsulin effect, the role of sex hormones and especially of progesterone (and synthetic progestins used in contraception) appears crucial. The presence of estrogen and progesterone receptors in the beta cellules of the islets of Langerhans suggests a direct effect of these hormones on the cellules. Estrogens however work by other mechanisms than insulin secretion. Experimental evidence indicates that during pregnancy, progesterone increases insulin release while human placental lactogen stimulates hyperplasia of the islets. The progestins derived from progesterone used in contraception have a parallel action. A slight elevation of blood sugar and insulinemia have been observed in oral contraceptive (OC) users. Only 3-5% of OC users develop true hyperglycemia. The changes are usually transitory and disappear on termination of OC use except in the small number of women predisposed to diabetes. The decreased glucose tolerance of OC users differs from true diabetes. Combined OCs favor vascular accidents and myocardial infarct in insulin-dependent diabetics. The mechanisms involved include deteriorating control of diabetes; effects on the serum lipids, coagulation factors, and blood pressure; and direct effects of estrogen on the vascular wall. Venous but not arterial vascular accidents decline with lower estrogen doses. Progestins probably play a more significant role from estrogens in decreasing glucose tolerance. Pregnanes, progestins derived from progesterone, do not appear to affect glucose tolerance. Among testosterone derivatives, the entrances decrease glucose tolerance slightly and the gonanes more strongly, also causing hyperinsulinism. But the new triphasic OCs with low levonorgestrel doses cause no significant changes in glucose tolerance even in women with histories of gestational diabetes. Long-acting progestin implants, vaginal rings, and injectables appear thus far to have minimal or no effects on glucose tolerance.^ieng


Subject(s)
Carbohydrate Metabolism , Gonadal Steroid Hormones/physiology , Contraceptives, Oral/pharmacology , Female , Humans
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