[The fight against rabies in Africa: from recognition to action]. / Lutte contre la rage en Afrique: du constat à l'action.

As a follow-up to the first AfroREB (Africa Rabies Expert Bureau) meeting, held in Grand-Bassam (Côte-d'Ivoire) in March 2008, African rabies experts of the Afro-REB network met a second time to complete the evaluation of the rabies situation in Africa and define specific action plans. About forty French speaking rabies specialists from Northern, Western and Central Africa and Madagascar met in Dakar (Senegal), from March 16th to 19th, 2009. With the participation of delegates from Tunisia, who joined the AfroREB network this year, 15 French speaking African countries were represented. Experts from the Institut Pasteur in Paris, the Alliance for Rabies Control, and the Southern and Eastern African Rabies Group (SEARG, a network of rabies experts from 19 English speaking Southern and Eastern African countries) were in attendance, to participate in the discussion and share their experiences. AfroREB members documented 146 known human rabies cases in all represented countries combined for 2008, for a total population of 209.3 million, or an incidence of 0.07 cases per 100,000 people. Even admitting that the experts do not have access to all reported cases, this is far from the WHO estimation of 2 rabies deaths per 100,000 people in urban areas and 3.6 per 100,000 in rural Africa. It was unanimously agreed that the priority is to break the vicious cycle of indifference and lack of information which is the main barrier to human rabies prevention.

[Intramuscular injections of quinine and tetanus at the Centre Hospitalier Universitaire of Brazzaville, Congo]. / Injections de quinine et tétanos au CHU de Brazzaville, congo.

Intramuscular injections are known for their iatrogenic complications. IM quinine is a routine procedure in Congo for drug resistant malaria management. In this short note, the authors evaluate tetanus relative to intramuscular injection of quinine among the cases of tetanus treated in the infectious diseases unit of "Centre Hospitalier Universitaire of Brazzaville". This study was conducted from January to December 2005 regarding 18 cases of tetanus among which 5 infected after intramuscular injection of quinine. Their level of severity was significantly higher with a high mortality rate (post intramuscular: 4 deaths out of 5; other cases: 3 deaths out of 13). Tetanus was generalized in 17 cases. A significant difference between the intramuscular and the non-intramuscular injection was observed regarding the pulse (p < 0.05), the level of severity (p < 0.005) and deaths (p < 0.005). Awareness-raising campaigns with populations and medical staff about the risks of intramuscular injections as well as vaccination schedule should be regularly implemented.

Fighting rabies in Africa: the Africa Rabies Expert Bureau (AfroREB).

Rabies experts from 14 francophone African countries met in Grand Bassam (Côte d'Ivoire), 10-13 March 2008. They presented the situation in their respective countries, acknowledging the lack of rabies awareness among the population, health care workers and health authorities. They recognized that infrastructure for the management of rabies exposure is scarce, modern vaccines are in limited quantity and immunoglobulins are lacking in most of their countries. They defined as a priority the need to have reliable figures on the disease burden, which is necessary for informed decision making and priority setting, and for applying for aid in controlling the disease. This meeting sealed the establishment of the Africa Rabies Expert Bureau (AfroREB).

[Simian smallpox (or monkey smallpox): study of 8 cases observed at Impfondo Hospital in Republic of Congo]. / Orthopoxvirose simienne (ou variole du singe): étude de 8 cas observés à l'hôpital d'lmpfondo de la République du Congo.

Monkeypox or simian smallpox is a viral disease whose clinical manifestations are similar to the human smallpox. In this study authors describe the care management and follow up of eight patients hospitalized at the Impfondo hospital in Congo. It was a transversal study conducted from the 23rd of May till the 7th of July 2003 at the District Hospital of Impfondo (Likouala province, Republic of Congo). We have analyzed 81 patient files hospitalized during that period. Using the Atlanta CDC criteria of case definition modified in 2003, monkeypox has been diagnosed in 8 patients. Our series has 4 male and 4 female patients. The mean age is 9.05 +/- 5.86 with extremes ranging from 5 months to 18 years old. The clinical manifestations included fever (n = 7), rash (n=8), articulations and muscles pains (n=2), mumps (n=4) and pruritus (n=6). 7 patients recovered among them 5 without complications and 2 with persistent hypochromic lesions for more than 6 weeks. The monkeypox strain responsible for these infections appeared not to be lethal to humans. However this study shows that monkeypox is an endemic public health risk in the sanitary district of Impfondo, within the Congo River basin. The endemic presence of monkeypox in the Congo basin could trigger a new outbreak if the viral strains involved here became lethal.

[Clinical management of patients and deceased during the Ebola outbreak from October to December 2003 in Republic of Congo]. / Prise en charge des malades et des défunts lors de l'epidémie de fièvre hémorragique due au virus Ebola d'octobre a décembre 2003 au Congo.

Outbreaks of Ebola virus hemorrhagic fever (EVHF) have been reported since 2001 in the Cuvette Ouest department, a forested area located in the Western North of Congo. At the end of October 2003 a new alarm came from this department which was quickly confirmed as being an epidemic of EVHF. The outbreak response was organized by the ministry of health with the assistance of an international team under the aegis of WHO. The case management of suspect cases was done in an isolation ward set up at the hospital; when patients refused to go to the ward for care they were isolated in their house according to a protocol "transmission risks reduction at home". Safe burials were performed by specialized teams which respected the major aspects of the funeral to allow the process of mourning of the families. An active surveillance system was set up in order to organize the detection of new cases and the follow-up of their contacts. A case definition was adopted. From October 11 to December 2, 2003, 35 cases including 29 deaths were reported, 16 cases were laboratory confirmed. The first four cases had been exposed to monkey meat (Cercopithecus nictitans). The epidemic spread was due to family transmission. The population interpretation of the disease, in particular questions around wizards and evil-minded persons, is a factor which must be taken into account by the medical teams during communication meetings for behavioral change of the populations. The case management of patient in isolation wards to prevent the transmission of the virus in the community remains the most effective means to dam up Ebola virus hemorrhagic fever outbreaks. The good perception by the community of the safe funerary procedures is an important aspect in the establishment of confidence relations with the local population.

Etude de la prevalence des anticorps anti-CMV seriques parmi la population congolaise seronegative et seropositive pour le VIH 1

L'objet de cette etude est d'apprecier la seroprevalence des anticorps de classe IgG et IgM dirigee contre le CMV parmi la population generale congolaise et de la comparer a celle observee chez les patients febriles seropositifs pour le VIH 1. Les bilans bacteriologiques; mycologiques et parasitaires sont negatifs. Les serums proviennent de 100 patients seropositifs pour le VIH 1 en ELISA; confirmes en WESTERN-BLOT et d'un groupe temoin de 100 sujets seronegatifs pour le VIH 1 en ELISA. [abstract terminated]

[Clinical, epidemiological and therapeutic aspects of purulent meningitis in the adult. Apropos of 74 cases treated at CHU of Brazzaville (Congo)]. / Aspects cliniques, épidémiologiques et thérapeutiques des méningites purulentes de l'adulte. A propos de 74 cas traités au CHU de Brazzaville (Congo).

During 2 years and 9 months, 74 patients were hospitalized to purulent meningitis at the Hospital of Brazzaville and 33 were bacteriologically confirmed. The pneumococcus was responsible in 24 cases (33.4%). The analysis of 74 files showed that 34 patients died, 40 were completely cured without any after effect. The factors for these bad prognosis are: the presence of signs of cerebral pains; a CSF cytology inferior to 500 cells/mm3; total CSF proteins inferior to 2 g/l and the time before hospitalisation superior to 5 days.