Subject(s)
Aeromonas veronii , Fasciitis, Necrotizing/drug therapy , Fasciitis, Necrotizing/surgery , Gram-Negative Bacterial Infections/drug therapy , Gram-Negative Bacterial Infections/surgery , Aeromonas veronii/isolation & purification , Aged , Anti-Bacterial Agents/administration & dosage , Cefepime/administration & dosage , Ciprofloxacin/administration & dosage , Combined Modality Therapy , Conservative Treatment , Consolidation Chemotherapy/adverse effects , Debridement , Drug Therapy, Combination , Fasciitis, Necrotizing/microbiology , Gram-Negative Bacterial Infections/complications , Humans , Leukemia, Myeloid, Acute/complications , Leukemia, Myeloid, Acute/drug therapy , Leukemia, Myeloid, Acute/microbiology , Male , Treatment OutcomeABSTRACT
In neonatal intensive care units, topical agents represent an increasing part of the infection control armamentarium. Fifty-one coagulase-negative staphylococci (CNS) isolated from catheter-associated bloodstream infections in very preterm neonates were investigated in this study: 41.2% exhibited decreased susceptibility to at least one antiseptic (chlorhexidine 12%, benzalkonium 24%, acriflavine 33%) and 61% were resistant to mupirocin. QacA/B, mupA and both genes were detected by polymerase chain reaction in 59%, 63% and 49% of CNS, respectively. Seventy-six percent of Staphylococcus epidermidis (5/5 pulsed-field-gel electrophoresis subgroups) and 11% of Staphylococcus capitis (1/3 subgroups) were multi-resistant. Skin antisepsis using low-concentration aqueous formulations and off-label mupirocin indications should benefit from a stewardship programme.
