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Epilepsia ; 37(2): 122-5, 1996 Feb.
Article in English | MEDLINE | ID: mdl-8635421

ABSTRACT

Neuron-specific enolase (NSE) is a marker of brain injury after acute neurologic insults. We report changes in serum NSE (s-NSE) in 25 patients (15 with epilepsy and 10 patients with nonepileptic events) during continuous inpatient video/EEG monitoring. s-NSE was significantly increased as compared with baseline and normal controls after the first ictal event in the epileptic group, especially in patients with secondarily generalized tonic-clonic seizures (p = 0.01), but s-NSE was not increased in patients with nonepileptic events. These preliminary data indicate that s-NSE may be increased after complex partial seizures--and generalized tonic-clonic seizures (GTCS).


Subject(s)
Brain/physiopathology , Electroencephalography , Epilepsy/enzymology , Hospitalization , Phosphopyruvate Hydratase/blood , Adult , Blood-Brain Barrier/physiology , Electroencephalography/methods , Epilepsy/diagnosis , Epilepsy, Complex Partial/diagnosis , Epilepsy, Complex Partial/enzymology , Epilepsy, Tonic-Clonic/diagnosis , Epilepsy, Tonic-Clonic/enzymology , Female , Humans , Male , Middle Aged , Monitoring, Physiologic , Psychophysiologic Disorders/diagnosis , Psychophysiologic Disorders/enzymology , Videotape Recording
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