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1.
Clin Orthop Relat Res ; 470(2): 630-6, 2012 Feb.
Article in English | MEDLINE | ID: mdl-22086506

ABSTRACT

When performing reconstruction of the ACL, the major complications that can arise include missed concomitant injuries, tunnel malposition, patellar fracture, knee stiffness, and infection. We review the complications that can occur as a result of errors made before, during, and after surgery.


Subject(s)
Anterior Cruciate Ligament Reconstruction/adverse effects , Anterior Cruciate Ligament/surgery , Anterior Cruciate Ligament/physiopathology , Anterior Cruciate Ligament Injuries , Biomechanical Phenomena , Humans , Recovery of Function , Treatment Outcome
2.
Clin Orthop Relat Res ; 470(3): 835-42, 2012 Mar.
Article in English | MEDLINE | ID: mdl-21739323

ABSTRACT

BACKGROUND: Young, active, skeletally mature patients have higher failure rates after various surgical procedures, including stabilization for shoulder instability and primary ACL reconstruction. It is unclear whether young, active, skeletally mature patients share similarly high failure rates after revision ACL reconstruction. QUESTIONS/PURPOSES: We therefore determined whether revision ACL reconstruction restores knee stability and allows young (younger than 18 years), active, skeletally mature patients to return to preinjury activity levels. PATIENTS AND METHODS: We retrospectively identified 36 patients who had an initial ACL reconstruction between the ages of 12 and 17 years (mean, 15.4 years) and subsequent revision between the ages of 13 and 18 years (mean, 16.9 years); of these, 2-year followup was available for 21 (75%). Mechanisms of primary graft failure included traumatic rerupture (23 noncontact, seven contact), persistent instability (five), and infection (one). One patient had open physes at the time of revision. All revisions were single-stage transosseous reconstructions. The minimum followup was 24 months (mean, 36 months; range, 24-63 months). RESULTS: At last followup, 19 of 21 patients had a negative or IA Lachman and 20 of 21 had a negative pivot shift. Mean International Knee Documentation Committee subjective score was 89 (range, 64-99). Eleven of the 21 patients returned to the same or higher activity/sport level as before their original injury. Two patients reported subjective knee instability, with two having repeat revision reconstruction for failure. CONCLUSIONS: Single-stage transosseous revision ACL reconstruction in young, active, skeletally mature patients restores knee stability but returns only 52% of patients to their prior level of activity or sport. LEVEL OF EVIDENCE: Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.


Subject(s)
Anterior Cruciate Ligament Reconstruction/methods , Bone-Patellar Tendon-Bone Grafting , Adolescent , Adult , Anterior Cruciate Ligament Injuries , Arthroscopy , Athletic Injuries/surgery , Female , Humans , Joint Instability/diagnostic imaging , Joint Instability/surgery , Knee Injuries/surgery , Male , Radiography , Range of Motion, Articular , Reoperation , Young Adult
3.
Arthroscopy ; 27(11): 1511-22, 2011 Nov.
Article in English | MEDLINE | ID: mdl-21963097

ABSTRACT

PURPOSE: Using 3-dimensional high-resolution magnetic resonance imaging (MRI), we sought to compare femoral and tibial tunnel position and resultant graft obliquity with single-bundle anterior cruciate ligament (ACL) reconstruction using transtibial (TT) or anteromedial (AM) portal femoral tunnel reaming techniques. METHODS: Thirty patients were prospectively enrolled after primary, autogenous bone-patellar tendon-bone ACL reconstruction by 2 groups of high-volume, fellowship-trained sports medicine surgeons. With the TT technique, an external starting point was used to maximize graft obliquity and femoral footprint capture. By use of high-resolution MRI and imaging analysis software, bilateral 3-dimensional knee models were created, mirrored, and superimposed. Differences between centroids for each femoral and tibial insertion, as well as corresponding ACL/graft obliquity, were evaluated with paired t tests and 2-sided Mann-Whitney nonparametric tests, with P < .05 defined as significant. RESULTS: No significant differences were observed between groups in position of reconstructed femoral footprints. However, on the tibial side, AM centroids averaged 0.8 ± 1.9 mm anterior to native ACL centroids, whereas the TT group centered 5.23 ± 2.4 mm posterior to native ACL centroids (P < .001). Sagittal obliquity was closely restored with the AM technique (mean, 52.2° v. 53.5° for native ACL) but was significantly more vertical (mean, 66.9°) (P = .0001) for the TT group. CONCLUSIONS: In this clinical series, AM portal femoral tunnel reaming more accurately restored native ACL anatomy than the TT technique. Although both techniques can capture the native femoral footprint with similar accuracy, the TT technique requires significantly greater posterior placement of the tibial tunnel, resulting in decreased sagittal graft obliquity. When a tibial tunnel is drilled without the need to accommodate subsequent femoral tunnel reaming, more accurate tibial tunnel position and resultant sagittal graft obliquity are achieved. LEVEL OF EVIDENCE: Level III, retrospective comparative study.


Subject(s)
Anterior Cruciate Ligament Reconstruction/methods , Anterior Cruciate Ligament/anatomy & histology , Knee Injuries/surgery , Knee Joint/anatomy & histology , Magnetic Resonance Imaging , Tendons/transplantation , Anterior Cruciate Ligament/surgery , Anterior Cruciate Ligament Injuries , Humans , Knee Joint/surgery , Retrospective Studies , Treatment Outcome
4.
J Infect Dis ; 202(6): 916-23, 2010 Sep 15.
Article in English | MEDLINE | ID: mdl-20698790

ABSTRACT

Because Helicobacter pylori persist for decades in the human stomach, the aim of this study was to examine the long-term course of H. pylori-specific serum immunoglobulin G (IgG) responses with respect to subclass and antigenic target. We studied paired serum samples obtained in 1973 and in 1994 in Vammala, Finland, from 64 healthy H. pylori-positive adults and from other healthy control subjects. H. pylori serum immunoglobulin A, IgG, and IgG subclass responses were determined by antigen-specific enzyme-linked immunosorbent assays. H. pylori-specific IgG1 and IgG4 subtype responses from 47 subjects were similar in 1973 and 1994, but not when compared with unrelated persons. H. pylori-specific IgG1:IgG4 ratios among the participants varied >1000-fold; however, 57 (89.1%) of 64 subjects had an IgG1:IgG4 ratio >1.0, consistent with a predominant IgG1 (Th1) response. Furthermore, ratios in individual hosts were stable over the 21-year period (r = 0.56; P < .001). The immune response to heat shock protein HspA was unchanged in 49 (77%) of the 64 subjects tested; of the 15 whose serostatus changed, all seroconverted and were significantly younger than those whose status did not change. These findings indicate that H. pylori-specific antibody responses are host-specific with IgG1:IgG4 ratios stable over 21 years, IgG1 responses predominating, and HspA seroconversion with aging.


Subject(s)
Antibodies, Bacterial/blood , Antigens, Bacterial/immunology , Carrier State/immunology , Helicobacter Infections/immunology , Helicobacter pylori/immunology , Adolescent , Adult , Bacterial Proteins/immunology , Enzyme-Linked Immunosorbent Assay , Female , Finland , Heat-Shock Proteins/immunology , Humans , Immunoglobulin A/blood , Immunoglobulin G/blood , Longitudinal Studies , Male , Middle Aged , Young Adult
5.
J Shoulder Elbow Surg ; 19(2 Suppl): 110-7, 2010 Mar.
Article in English | MEDLINE | ID: mdl-20188276

ABSTRACT

INTRODUCTION: Elbow ulnar collateral ligament (UCL) reconstruction has become the standard of care for the throwing athlete with a symptomatic ruptured or insufficient ligament and the desire to resume competitive play. Since Jobe's initial description of UCL reconstruction, the technique has evolved. A novel modification was the "docking" technique developed by Altchek. Subsequently, the docking technique as originally described was slightly modified. Arthroscopy is no longer routinely performed, and in some cases, a 3-strand graft is used. MATERIALS AND METHODS: We treated 21 overhand athletes with clinical and radiographic evidence of UCL insufficiency with ligament reconstruction using a modified version of the docking technique using a 3-strand graft. There were 5 professional, 11 college, and 5 high school baseball players in the reconstructed group. Athletes were evaluated postoperatively by use of the Conway Scale. RESULTS: Of the 21 patients who underwent the modified docking technique with a three-strand graft, 19 (90%) had excellent results. There were 2 good results and no complications. DISCUSSION: UCL reconstruction can successfully treat athletes with UCL insufficiency. Several different reconstruction techniques have been described. By use of the docking and modified docking techniques, good to excellent results can be achieved in the majority of cases with a low complication rate.


Subject(s)
Baseball/injuries , Collateral Ligaments/surgery , Elbow Joint/surgery , Orthopedic Procedures/methods , Plastic Surgery Procedures/methods , Adolescent , Adult , Collateral Ligaments/injuries , Cumulative Trauma Disorders/surgery , Humans , Male , Rupture , Treatment Outcome , Ulnar Nerve/surgery , Young Adult
6.
Clin Orthop Relat Res ; 468(7): 1971-7, 2010 Jul.
Article in English | MEDLINE | ID: mdl-20174901

ABSTRACT

BACKGROUND: Treating ACL injuries in prepubescent patients requires balancing the risk of chondral and meniscal injuries associated with delaying treatment against the risk of growth disturbance from early surgical reconstruction. Multiple physeal respecting techniques have been described to address this vulnerable population; however, none restore the native ACL attachments while keeping the graft and fixation entirely in the epiphysis. DESCRIPTION OF TECHNIQUE: We describe a technique of all-epiphyseal ACL reconstruction for use in prepubescent skeletally immature patients. Intraoperative CT scanning with three-dimensional (3-D) reconstruction was used to confirm the precise localization of the all-epiphyseal femoral and tibial tunnels. The femoral tunnel is drilled entirely in the epiphysis of the lateral femoral condyle. The tibial tunnel is drilled from inside-out to the level of the tibial physis using a retrograde drill. Fixation of the soft tissue graft is achieved with a retrograde interference screw in the tibia and an interference screw in the femur. PATIENTS AND METHODS: Case examples are presented for three boys aged 10-12, Tanner Stage 1 development, with a minimum followup of 1 year. RESULTS: All three patients had stable knees based on Lachman and KT-1000 testing and no evidence of growth disturbance. All had full ROM and symmetric strength for knee flexion and extension. All patients returned to their sports activities using a custom ACL brace. CONCLUSIONS: Although longer-term followup will be necessary, this technique provides for an anatomic all-epiphyseal-based ACL reconstruction using intraoperative 3-D imaging to minimize the risk of growth disturbance. LEVEL OF EVIDENCE: Level IV, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.


Subject(s)
Anterior Cruciate Ligament/surgery , Epiphyses/surgery , Knee Injuries/surgery , Orthopedic Procedures/methods , Age Factors , Child , Femur/surgery , Humans , Imaging, Three-Dimensional/methods , Male , Plastic Surgery Procedures , Treatment Outcome
7.
Am J Sports Med ; 38(3): 527-31, 2010 Mar.
Article in English | MEDLINE | ID: mdl-20093421

ABSTRACT

BACKGROUND: Men's intercollegiate lacrosse is played at a fast pace and with significant force. Glove protection is required. However, the thumb is at risk because of contact with opponents' sticks, the ball, other players, and the ground or artificial surface. PURPOSE: To characterize patterns of hand injuries in men's intercollegiate lacrosse and to compare them with those in similar intercollegiate stick-handling sports that require gloves. STUDY DESIGN: Descriptive epidemiology study. METHODS: The National Collegiate Athletic Association (NCAA) Injury Surveillance System was utilized to evaluate thumb injuries in intercollegiate stick-handling sports (men's lacrosse, women's lacrosse, and men's ice hockey) during 16 intercollegiate seasons. Injuries were defined as events requiring an athlete to seek medical treatment and miss competition. Data were collected for injuries to the thumb, phalanges, and hand. Descriptive statistics were performed to calculate rates of injury per 1000 athlete-exposures and the relative exposure of the thumb with respect to total hand injuries. chi(2) testing with the Yates correction for continuity was performed to determine differences in proportions of injury among the 3 sports studied. RESULTS: During 16 intercollegiate seasons, there were 692 thumb, finger, and hand injuries in 3 038 255 athlete-exposures. Total thumb injuries were significantly higher in men's lacrosse, accounting for 59.4% of total hand injuries, when compared with women's lacrosse (42%) and men's ice hockey (35.8%) (P <.001). Thumb fractures and contusions were each also found to be significantly more prevalent (P <.001) when compared with women's lacrosse and men's ice hockey. CONCLUSION: Men's intercollegiate lacrosse requires the use of gloves; nonetheless, injury rates of the thumb are significantly elevated in this sport compared with other gloved, stick-handling sports. Recommendations include the development of gloves with improved thumb protection.


Subject(s)
Athletic Injuries/epidemiology , Hand Injuries/epidemiology , Racquet Sports/injuries , Thumb/injuries , Athletic Injuries/prevention & control , Female , Gloves, Protective , Hand Injuries/prevention & control , Hockey/injuries , Humans , Male
8.
Med Sci Sports Exerc ; 40(12): 2022-6, 2008 Dec.
Article in English | MEDLINE | ID: mdl-18981949

ABSTRACT

PURPOSE: Protective gloves are worn for stick-handling sports, including ice hockey, men's lacrosse, and women's lacrosse, but are not mandated for women's field hockey. The purpose of this study is to evaluate whether collegiate field hockey players are at increased risk for significant hand injuries compared with stick-handling athletes who wear protective gloves. METHODS: In this descriptive, epidemiological study, data were gathered from the NCAA Injury Surveillance System reported over a 16-yr period pertaining to 1036 hand and phalangeal injuries occurring in 3,752,547 exposures in stick-handling athletes (field hockey, ice hockey, men's lacrosse, and women's lacrosse). An exposure was defined as an athlete's participation in an individual practice or game. Data were analyzed for total injuries, fractures, ligamentous injuries, contusions, and lacerations and calculated as rates per 1000 exposures. Rates were compared among the four stick-handling sports. RESULTS: Odds ratios (OR) of hand injuries, hand fractures, phalangeal injuries, and phalangeal fractures were significantly higher in the ungloved (field hockey) athletes than in the gloved athletes (P < 0.01). The odds of a hand injury (OR = 2.12), hand fracture (OR = 1.93), phalangeal injury (OR = 4.19), or phalangeal fracture (OR = 4.04) occurring in ungloved players were significantly higher than for gloved players. CONCLUSION: Of participants in four stick-handling sports, collegiate field hockey players have significantly higher odds of sustaining hand or phalangeal injuries. Wearing gloves is a protective measure common in ice hockey and men's and women's lacrosse. However, it is not the current practice in field hockey. We recommend the use of protective gloves in collegiate field hockey practice and competition.


Subject(s)
Athletic Injuries/epidemiology , Hand Injuries/epidemiology , Hockey/injuries , Female , Gloves, Protective , Humans , Male , Population Surveillance , United States/epidemiology
9.
Med Sci Sports Exerc ; 40(8): 1362-7, 2008 Aug.
Article in English | MEDLINE | ID: mdl-18614960

ABSTRACT

PURPOSE: Methicillin-resistant Staphylococcus aureus (MRSA) has been recognized as a serious skin infection in the athletic population. Literature in reference to football players has been sparse. We sought to better elucidate circumstances surrounding such infections in collegiate football players. METHODS: Data from three Division-I collegiate football programs were consolidated and analyzed. Variables included presence of MRSA infection, timing of occurrence, body location involved, lesion morphology, need for surgical treatment, and antibiotic route. Data were analyzed statistically to evaluate player position, body location, and timing of occurrences. RESULTS: Of the 491 collegiate football players, 33 (6.7%) were diagnosed with MRSA infections. Cutaneous manifestations included abscess (70%), cellulitis (16%), folliculitis, impetigo, and necrotizing fasciitis. Of the infections, 90% underwent surgical drainage, whereas 27% received intravenous antibiotics. Extremity infections (n = 30) greatly exceeded truncal infections (n = 7); the most common locations were the elbow (n = 11), knee (n = 6), leg (n = 4), and forearm (n = 4). There was no difference in occurrence by player position. Infections occurred predominantly in the first third of the season (P < 0.001, chi-square test) and significantly decreased as the season progressed. CONCLUSION: MRSA infections involving football players are becoming more common. This study documents player positions involved, timing of occurrence in the season, location and type of infections, and required treatment. Exposed extremities may predispose to infection due to risk for minor trauma and direct contact with bacteria. As infection risk seems to be independent of position, all players should observe protective measures. Although most infections occur earlier in the season, physicians should remain alert for infection occurrences throughout the season.


Subject(s)
Football , Methicillin-Resistant Staphylococcus aureus/drug effects , Staphylococcal Infections/epidemiology , Adult , Humans , Methicillin-Resistant Staphylococcus aureus/isolation & purification , Staphylococcal Infections/drug therapy , Staphylococcal Infections/physiopathology , United States/epidemiology , Universities/statistics & numerical data
10.
Clin Orthop Relat Res ; 466(9): 2276-81, 2008 Sep.
Article in English | MEDLINE | ID: mdl-18584263

ABSTRACT

UNLABELLED: Internal fixation of a traumatic osteochondral defect presents a challenge in terms of obtaining anatomic reduction, fixation, and adequate compression for healing. Fixation with countersunk intraarticular screws, Herbert screws, bioabsorbable screws and pins, mini-cancellous screws, and glue tissue adhesive have been reported with varying results. We present an alternative fixation method used in two patients for femoral condylar defects that achieved anatomic reduction with compression via a cruciate-shaped suture bridge construct tied down over a bony bridge. This fixation method allowed early passive range of motion and permitted high-quality MRI for followup of fracture healing and articular cartilage integrity. Arthroscopic examination of one of two patients at 6 months followup showed the gross appearance of a healed, anatomically reduced fracture. With 1 year followup for one patient and 2 years for the other, the patients have resumed activity as tolerated with full, painless range of motion at the knee. Longer-term outcomes are unknown. However, the suture bridge is an alternative means of fixation with encouraging early results for treatment of traumatic osteochondral fragments in the knee. LEVEL OF EVIDENCE: Level IV, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.


Subject(s)
Femoral Fractures/surgery , Fracture Fixation, Internal/methods , Suture Techniques , Adult , Arthroscopy , Cartilage/injuries , Female , Humans , Knee Injuries/surgery , Magnetic Resonance Imaging , Male
11.
Clin Orthop Relat Res ; 466(7): 1671-7, 2008 Jul.
Article in English | MEDLINE | ID: mdl-18373126

ABSTRACT

UNLABELLED: Open exposure of the posterolateral corner of the knee is challenged by limitations of posterolateral ligamentous tissues and posterior neurovascular structures. We have used a modification of a lateral femoral epicondyle osteotomy, described historically for surgical management of posterolateral rotatory instability, as an approach to the posterolateral intraarticular structures. The historic technique for ligamentous reconstruction has been abandoned because its nonanatomic fixation does not restore ligamentous isometry. In this report, osteotomy of a bone block from the lateral femoral epicondyle is used to access the joint space. The lateral collateral ligament is reflected distally and posteriorly through traction on the block. Once the intraarticular disorder has been addressed, the lateral femoral epicondyle is secured in its native, anatomic position, thereby restoring isometry and normal joint mechanics after surgery. This technique has been used successfully to address posterolateral articular disorders on femoral and tibial sides. Postoperative magnetic resonance imaging verified restoration of lateral collateral ligament anatomy. Physical examination at 0 degrees and 30 degrees knee flexion showed clinical stability at all postoperative evaluations through 6 and 10 months followup. Using this technique, intraarticular disorders at the posterolateral corner may be addressed in an open manner with anatomic reduction and preserved postoperative function of the lateral collateral ligament. LEVEL OF EVIDENCE: Level V, expert opinion.


Subject(s)
Femur/surgery , Joint Instability/surgery , Knee Injuries/surgery , Osteotomy/methods , Adolescent , Adult , Humans , Knee Joint/surgery , Male
12.
Orthopedics ; 31(6): 612, 2008 Jun.
Article in English | MEDLINE | ID: mdl-19292333

ABSTRACT

Traumatic arteriovenous fistulae are rare injuries in the pediatric population. Most are caused by penetrating injuries or are post-surgical in nature. Fistulae resulting from non-penetrating injuries are often missed early in the course of physical examination. This occurs due to the absence of clinical signs of arterial or venous injury, despite the close proximity of the affected vessels to point of injury. Likewise, signs and symptoms of post-surgical vascular injury may be difficult to discern from normal postoperative discomfort. The astute clinician must be on alert for unusual presentations of vascular injury to intervene in an expeditious manner. This article presents a series of vascular complications following either blunt injury or surgical management of the lower extremity in children who presented to our facility between November 2004 and December 2005.


Subject(s)
Arteriovenous Fistula/etiology , Arteriovenous Fistula/surgery , Leg Injuries/complications , Leg Injuries/surgery , Lower Extremity/blood supply , Wounds, Nonpenetrating/complications , Wounds, Nonpenetrating/surgery , Adolescent , Child , Humans , Male , Treatment Outcome
13.
Semin Musculoskelet Radiol ; 11(1): 83-90, 2007 Mar.
Article in English | MEDLINE | ID: mdl-17665354

ABSTRACT

Contracture of the gastrocnemius musculature is a prevalent finding in the setting of foot and ankle pathology. Tightness of the posterior musculotendinous structures in the leg limits ankle range of motion and affects an equinus posture of the foot. Increased contact pressures are generated in the plantar foot with weightbearing. The resultant overload of the ligaments and the intrinsic muscles of the midfoot and forefoot is manifest in a variety of pathologic processes. The altered mechanics contributes to, among other conditions, ankle impingement, plantar fasciitis, midfoot arthritis, posterior tibial tendon dysfunction, forefoot overload, diabetic ulceration, and Charcot arthropathy. Effective management of these conditions includes addressing the underlying gastrocnemius contracture as well as the related foot and ankle pathology. Here we describe the underlying biomechanical abnormalities and radiographic findings in these pathological conditions of the foot and ankle associated with gastroequinus contracture. An awareness and understanding of the pathomechanics should enable the radiologist to better appreciate the form and function associated with the image.


Subject(s)
Ankle Joint , Contracture/physiopathology , Foot Diseases/etiology , Muscle, Skeletal , Ankle Joint/diagnostic imaging , Biomechanical Phenomena , Diabetic Neuropathies/physiopathology , Humans , Joint Diseases/etiology , Joint Diseases/pathology , Radiography
14.
Clin J Sport Med ; 15(1): 9-13, 2005 Jan.
Article in English | MEDLINE | ID: mdl-15654185

ABSTRACT

OBJECTIVE: To identify demographic and anthropometric risk factors for intra-articular (IA) injuries observed during ACL reconstruction. We hypothesize that significant associations exist among height, weight, and body mass index (BMI) with IA injuries when ACL tear occurs. DESIGN: This observational study of a prospective multi-investigator ACL database used logistic and Poisson regression analysis to assess independent predictors of IA injuries. SETTING: Vanderbilt Sports Medicine and affiliated tertiary care center. PATIENTS: Patients undergoing unilateral ACL reconstruction without prior injury to either knee were identified from a detailed prospective ACL reconstruction database. Four hundred fifty-six patients met inclusion/exclusion criteria. INTERVENTIONS: Per inclusion criteria, all patients underwent unilateral ACL reconstruction after assessment of injury profile. MAIN OUTCOME MEASUREMENTS: The ACL database was initiated in 1990 to identify demographic, anthropometric, and mechanistic variables associated with intra-articular injury. RESULTS: Height best predicted tibial and patellar damage. BMI better predicted medial femoral condyle lesions, whereas weight better predicted lateral and patellofemoral injury. BMI and weight equally predicted injury to menisci and medial tibial plateau. Through different outcomes, age (odd ratio [OR], 1.49; 95% CI, 1.02-2.16), height (OR, 2.66; 95% CI, 1.52-4.65), weight (OR, 1.02; 95% CI, 1.01-1.04), and BMI (OR, 1.24; 95% CI, 1.004-1.53) were all significant predictors of intra-articular injury. CONCLUSIONS: This is the first report using multivariable analysis of age, height, weight, and BMI to evaluate associations with IA injuries after ACL rupture observed during ACL reconstruction. We hypothesize that athletes possibly could reduce risk of certain IA pathologies with maintenance of lower body weight and BMI and thus potentially improve long-term functional outcomes after ACL reconstruction.


Subject(s)
Anterior Cruciate Ligament Injuries , Body Height , Body Mass Index , Body Weight , Knee Injuries/etiology , Adult , Age Factors , Anterior Cruciate Ligament/surgery , Female , Humans , Knee Injuries/diagnosis , Logistic Models , Male , Odds Ratio , Poisson Distribution , Sex Factors
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