1.
J Med Chem
; 22(8): 1000-2, 1979 Aug.
Article
in English
| MEDLINE
| ID: mdl-490530
ABSTRACT
Alkenylidene bisphenols are prepared by condensation of an appropriate phenol with a haloacetaldehyde, followed by base-induced elimination, or by condensation of the corresponding aryl methyl ether, elimination, and deprotection of the phenol with boron tribromide. The resulting compounds may be further elaborated by reactions on the aromatic nucleus. A series of 13 such compounds showed activity against Staphylococcus aureus; the most active was 1,1-dichloro-2-(3-allyl-5-chloro-2-hydroxphenyl)-2-(5-chloro-2-hydroxyphenyl)ethylene (16), MIC 0.16 microgram/mL. 1,1-Dichloro-2,2-bis(5-chloro-2-hydroxyphenyl)ethylene (6) was similar in its activity and spectrum to hexachlorophene.
Subject(s)
Anti-Infective Agents, Local/chemical synthesis , Chlorophenols/chemical synthesis , Chemical Phenomena , Chemistry , Chlorophenols/pharmacology , Staphylococcus aureus/drug effects
2.
J Org Chem
; 41(1): 159-60, 1976 Jan 09.
Article
in English
| MEDLINE
| ID: mdl-1244456
3.
J Agric Food Chem
; 23(3): 359-64, 1975.
Article
in English
| MEDLINE
| ID: mdl-1150977