ABSTRACT
Commercially produced oil furnace carbon black (Chemical Abstract Service Registry No. 1333-86-4) has been evaluated by five different assay for genetic activity. These were the Ames Salmonella typhimurium reverse mutation test, sister chromatid exchange test in CHO cells, mouse lymphoma test, cell transformation assay in C3H/10T1/2 cells, and assay for genetic effects in Drosophila melanogaster. Limited cellular toxicity was exhibited but no significant genetic activity was noted.
Subject(s)
Air Pollutants, Occupational/toxicity , Air Pollutants/toxicity , Carbon/toxicity , Mutagens , Animals , Cells, Cultured , Clone Cells/drug effects , Cricetinae , Female , Lymphoma/physiopathology , Male , Mutagenicity Tests , Neoplasms, Experimental/physiopathology , Salmonella typhimurium/genetics , Sister Chromatid Exchange/drug effects , Y Chromosome/drug effectsABSTRACT
A male-sterile mutant, ms(1)7, of Drosophila melanogaster is defective in post-ejaculatory sperm function. The mutant gene is located at one of at least five male fertility loci in 18F through section 20 of the polytene X-chromosome. It is proposed that the ms(1)7+ gene product modifies a component of the sperm head. A nearby gene may be functionally related to ms(1)7+.