1.
Mol Divers
; 21(4): 925-932, 2017 11.
Article
in English
| MEDLINE
| ID: mdl-28766257
ABSTRACT
A multicomponent domino synthesis has been developed for the preparation of 2-aminopyrimidines from ß-dicarbonyl compounds, N,N-dimethylformamide dimethyl acetal, and cyanamide. The protocol was used for the regioselective preparation of 4-amide/ester/ketone substituted 2-aminopyrimidines. Twelve 2-aminopyrimidines were isolated in good yields (56-93%).