ABSTRACT
Nephrogenic adenoma is a rare metaplastic benign lesion of urothelium in response to genitourinary tract procedures, chronic infection, trauma, urinary calculi and immunosuppressive therapy after renal transplantation. It has been reported to occur throughout the urinary tract especially, in the urinary bladder. We report a case of nephrogenic adenoma arising from the lower end of the right ureter with clinical and radiological features suspicious of carcinoma.
Subject(s)
Adenoma/pathology , Ureteral Neoplasms/pathology , Humans , Keratin-7/metabolism , Kidney Tubules/pathology , Magnetic Resonance Imaging , Male , Middle Aged , Ureteral Neoplasms/diagnostic imaging , Urography , Urothelium/pathologyABSTRACT
Kaposi's sarcoma is a tumour of reticuloendothelial system. Non-epidemic Kaposi's sarcoma limited to the penile involvement should be aggressively treated because it is rarely associated with diffuse organ involvement localized surgical excision or small-field external beam or electron beam radiation has been effective. In this case, we presented a man 53 years old, who presents with a papular indolent lesion on the glans penis, which is reported as a Kaposi sarcoma after excision of the lesion.
Subject(s)
HIV Seronegativity , Penile Neoplasms , Sarcoma, Kaposi , Humans , Male , Middle Aged , Penile Neoplasms/diagnosis , Sarcoma, Kaposi/diagnosisABSTRACT
OBJECTIVE: In this series of ductal carcinoma of the breast, immunoexpression of antimetastasis gene nm23 and tenascin was examined and the role in prognosis was investigated by correlation with the tumour grade and stage, and ER/PR immunoexpression. MATERIAL AND METHODS: In this study 27 ductal carcinomas of the breast were analysed for expression of tenascin and nm23 antimetastasis genes by immunohistochemistry. RESULTS: The results of our study revealed a statistically significant correlation between nm23-H1 immunoexpression and lymph node metastasis. We also found a statistically significant correlation between tenascin and nm23-H1 immunoexpression. Our results suggest that tenascin limits tumour spread. CONCLUSION(S): Antimetastasis gene expression can be used in predicting lymph node metastasis in ductal carcinomas of the breast.
Subject(s)
Biomarkers, Tumor/metabolism , Breast Neoplasms/metabolism , Carcinoma, Ductal, Breast/metabolism , Monomeric GTP-Binding Proteins/metabolism , Nucleoside-Diphosphate Kinase , Tenascin/metabolism , Transcription Factors/metabolism , Adult , Aged , Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/pathology , Female , Humans , Immunohistochemistry , Lymphatic Metastasis/diagnosis , Middle Aged , NM23 Nucleoside Diphosphate Kinases , Neoplasm Staging , PrognosisABSTRACT
In this retrospective study, we investigated the HPV DNA occurrence in 21 laryngeal and 26 primary lung squamous cell carcinomas. Nonisotopic in situ hybridization (NISH) technique was performed with commercially available digoxigenin-labelled DNA probes for HPV screening. Subtyping for HPV subtypes 6/11, 16/18 and 31/33 was also performed. We observed HPV DNA signals in 10 (47.6%) cases of laryngeal SCC and in only 3 (11.5%) cases of lung SCC. Typing showed signals of HPV 6/11, 16/18 and 31/33 infection in 80%, 40%, 30% of the laryngeal carcinomas, respectively. In the lung, we demonstrated type 16/18 positivity in two and type 6/11 in one of the HPV-positive cases. We found a statistically significant correlation between HPV infection and tumour recurrence (p < 0.035) in laryngeal carcinomas, but not between HPV presence and tumour stage or grade in neither larynx nor lung.
