1.
Bioorg Med Chem Lett
; 10(24): 2759-63, 2000 Dec 18.
Article
in English
| MEDLINE
| ID: mdl-11133085
ABSTRACT
A library of 80 analogues of the antibacterial compound mureidomycin was prepared using solid-phase chemistry techniques.
Subject(s)
Anti-Bacterial Agents/chemical synthesis , Anti-Bacterial Agents/pharmacology , Combinatorial Chemistry Techniques , Microbial Sensitivity Tests , Nucleosides/chemical synthesis , Nucleosides/chemistry , Nucleosides/pharmacology , Structure-Activity Relationship
2.
Bioorg Med Chem Lett
; 9(7): 1023-8, 1999 Apr 05.
Article
in English
| MEDLINE
| ID: mdl-10230632
ABSTRACT
A preliminary exploration of analogues of 4,5-bis(3,5-dichlorophenyl)-2-trifluoromethyl-1H-imidazole, 1, as novel antibacterial agents was carried out to determine the basic features of the structure responsible for the observed biological activity. The presence of two aryl rings, the imidazole NH and either a good electron withdrawing group or an aldehyde or amino group at C-2 were required for good levels of activity against methicillin resistant Staphylococcus aureus (MRSA).
