ABSTRACT
Linoleic acid (C18: 2n-6) is a free fatty acid considered as essential in man; this is mainly based on the fact that man is incapable of its synthesis and that its deficiency accounts for a defined clinical picture. Linoleic acid (LA) is an essential component of cellular membranes and plays, therefore, an important role in cells; moreover, it plays a functional part on account of its precursory position of eicosanoids. For these reasons, the skin is a preferential target in case of LA deficiency, which alters the barrier function of the skin as well as the immunoregulation of the epidermic homeostasis. Man's requirement of LA has been estimated 4% of the total energy supply, i.e. 7-10 g daily. Deficiency of LA may arise from various factors: insufficient supply; metabolic anomalies (mostly due to advanced age and hepatopathies which may particularly alter the metabolic process of desaturation). Symptoms due to LA deficiency are xerosis and erythematosquamous dermatitis. The clinical picture being non-specific may be confused with other vitamin deficiencies, all the more because of metabolic interactions between these vitamins and various trace elements. Thus--in order to make the diagnosis--plasmatic fatty acid fractioning by means of gaseous phase chromatography is indicated in case of therapy-resistant eczematous dermatitis associated with malnutrition. These findings may be confirmed by measuring either the ratio of eicosatrienoic acid vs. arachidonic acid or the ratio of LA vs. arachidonic acid (in case of a disturbed metabolism of fatty acids). The treatment consists of regular oral, parenteral or topical application of essential fatty acids. Topical administration is especially indicated, because these patients, although often suffering from impaired intestinal absorption, reveal a tenfold percutaneous absorption rate of fatty acids.
Subject(s)
Dermatitis/etiology , Linoleic Acids/deficiency , Aged , Alcoholism/complications , Humans , Linoleic Acid , MaleABSTRACT
6 cases of hypersensitivity to Tixocortol pivalate and 3 to Amcinonide are reported. The 9 female patients all presented with features of contact dermatitis.
Subject(s)
Dermatitis, Contact/etiology , Facial Dermatoses/chemically induced , Hydrocortisone/analogs & derivatives , Triamcinolone/analogs & derivatives , Administration, Topical , Adult , Aged , Chemical Phenomena , Chemistry , Female , Humans , Hydrocortisone/administration & dosage , Hydrocortisone/adverse effects , Middle Aged , Triamcinolone/administration & dosage , Triamcinolone/adverse effectsABSTRACT
Observations concerning contact dermatitis to derivatives of isothiazolin-3-one are reported. A systematic review of the literature of previously published cases is reported. A verified contact dermatitis to benzisothiazolin-3-one of a laborer in a rubber factory is discussed. Another case of occupational dermatitis concerns an allergy to a commercial product, containing 2-n-octyl-4-isothiazolin-3-one as a preservative and utilized by shoe factory workers. Additionally, cases of an allergy to cosmetic preparations, containing a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, are elaborated.
Subject(s)
Dermatitis, Atopic/chemically induced , Dermatitis, Contact/etiology , Dermatitis, Occupational/chemically induced , Thiazoles/adverse effects , Adult , Female , Humans , Male , Middle AgedABSTRACT
Report of an unusual verrucous nevus of the scalp which was seen in a 11 year old girl and her mother. The diagnosis was verified by histological examination. Therapy was only symptomatically.
Subject(s)
Nevus/genetics , Scalp , Skin Neoplasms/genetics , Adult , Child , Diagnosis, Differential , Female , Humans , Nevus/pathology , Scalp/pathology , Skin Neoplasms/pathologyABSTRACT
Report of a 5 year old Yugoslav girl with xeroderma pigmentosum. This disease was associated with ophthalmological symptoms such as photophobia, blepharospasm and a tumor of the cornea. Based on this case the ocular abnormalities in xeroderma pigmentosum are reviewed in the literature.
Subject(s)
Eye Diseases/etiology , Xeroderma Pigmentosum/pathology , Child, Preschool , Eye Diseases/pathology , Female , HumansABSTRACT
Case history of a 68 years old patient with pyoderma gangrenosum and IgG-paraproteinemia with kappa type light chains. Paraproteins which are observed in pyoderma gangrenosum without overt myeloma could represent early symptoms of plasmocytoma.
