ABSTRACT
A novel pentamethinium salt was synthesized with an unforeseen expanded conjugated quinoxaline unit directly incorporated into a pentamethinium chain. The compound exhibited high fluorescence intensity, selective mitochondrial localization, high cytotoxicity, and selectivity toward malignant cell lines, and resulted in remarkable in vivo suppression of tumor growth in mice.
Subject(s)
Antineoplastic Agents/chemistry , Hexamethonium/chemistry , Neoplasms/drug therapy , Quinoxalines/chemistry , Animals , Antineoplastic Agents/therapeutic use , Cell Line, Tumor , Cyclization , Hexamethonium/therapeutic use , Mice , Neoplasms/pathology , Quinoxalines/therapeutic useABSTRACT
This review summarizes recent developments in the area of porphyrin chemistry in the direction of biological applications. Novel synthetic methodologies are reviewed for porphyrin synthesis, porphyrin analog synthesis, stable porphyrinogens -- calixpyrroles, expanded porphyrins. Unique biological properties of those compounds are desribed with focus on photodynamic therapy (PDT) and molecular recognition properties. Special attentions given to metalloporphyrins with potential to affect heme degradation and CO formation.
