ABSTRACT
The overwhelming postsplenectomy infection syndrome (OPSI) is a fulminant sepsis that is mainly caused by Streptococcus pneumoniae and is characterized by a particular high mortality. Patients whose spleen was removed due to a hematological disease are at special risk. Even after the recommended immunization against Streptococcus pneumoniae 20-30 % of these patients do not develop an adequate level of antibody response. Therefore, this particular group of patients must be trained how to behave in case of fever and need to obtain immediate specific sepsis therapy with antibiotic prophylaxis.
Subject(s)
Pneumococcal Infections/therapy , Postoperative Complications/therapy , Splenectomy/adverse effects , Systemic Inflammatory Response Syndrome/etiology , Systemic Inflammatory Response Syndrome/therapy , Anti-Bacterial Agents/therapeutic use , Antibiotic Prophylaxis , Antibodies, Bacterial/immunology , Blood Cell Count , Blood Chemical Analysis , Blood Coagulation Disorders/etiology , Blood Coagulation Disorders/therapy , Blood Transfusion , Diagnosis, Differential , Fatal Outcome , Heart-Assist Devices , Humans , Male , Middle Aged , Palliative Care , Pneumococcal Infections/etiology , Postoperative Complications/diagnosis , Risk , Systemic Inflammatory Response Syndrome/diagnosis , Tomography, X-Ray ComputedSubject(s)
Appendiceal Neoplasms/diagnosis , Appendiceal Neoplasms/surgery , Carcinoma in Situ/diagnosis , Carcinoma in Situ/surgery , Cystadenoma, Mucinous/diagnosis , Cystadenoma, Mucinous/surgery , Rare Diseases , Appendectomy , Appendiceal Neoplasms/pathology , Appendix/pathology , Carcinoma in Situ/pathology , Cystadenoma, Mucinous/pathology , Diagnosis, Differential , Humans , Laparoscopy , Male , Middle Aged , Multidetector Computed TomographyABSTRACT
Cytogenetic analyses were performed on 340 follicular thyroid adenomas and goiters after short-term culture. Clonal chromosomal changes were found in 67 cases. Trisomy 7 as the sole abnormality or along with other trisomies was the most frequent type of aberration (19 cases). Other recurrent numerical changes were loss of chromosome 22 (4 cases) and the second X or the Y chromosome (5 cases). Translocations involving 19q13 (12 cases) were frequent structural chromosomal changes. Dicentric chromosomes or telomeric associations were frequent in goiters (12 cases). After a histopathologic classification of all cases, we have correlated the cytogenetic findings with the histology of the tumors. Only 8.4% of the goiters showed clonal abnormalities, whereas 44.9% of the adenomas revealed clonal abnormalities. Furthermore, simple clonal changes were predominantly found in goiters and complex changes in adenomas. The most impressive correlation was found in the group of lesions with trisomy 7. Although all but one lesion with one or two additional trisomies were goiters, those having three or more additional trisomies were all adenomas or adenomatous goiters.
Subject(s)
Adenoma/genetics , Adenoma/pathology , Thyroid Diseases/genetics , Thyroid Diseases/pathology , Thyroid Neoplasms/genetics , Thyroid Neoplasms/pathology , Cells, Cultured , Chromosome Aberrations , Chromosomes, Human, Pair 19 , Chromosomes, Human, Pair 7 , Clone Cells , Humans , Translocation, Genetic , TrisomyABSTRACT
Cytogenetic studies of thyroid hyperplasias and adenomas have shown that besides cases with an apparently normal karyotype different groups of cytogenetic abnormalities exist. Herein we describe the cytogenetic analyses of two benign thyroid tumors with deletions of the short arm of chromosome 2. A similar case has been described previously. Besides the previously well-established subgroups, alterations of chromosome 2 may thus characterize a new cytogenetic subgroup of benign thyroid tumors.
