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Seizure ; 53: 103-109, 2017 Dec.
Article in English | MEDLINE | ID: mdl-29169028

ABSTRACT

PURPOSE: Depressive and anxiety disorders are frequent among people with epilepsies. There are, however, only few longitudinal studies, which examine the relationship between these comorbid psychiatric disorders and epilepsy-related variables. Thus, we investigated the interrelationships of depression and anxiety symptoms with seizure frequency across time. METHODS: Before admittance to an epilepsy center (T1) and six months after discharge (T2), patients (n=198) with mainly difficult-to-treat epilepsies completed the Hospital Anxiety and Depression Scale (HADS). Correlation and path analyses were conducted. RESULTS: Depression and anxiety symptoms (HADS) as well as seizure frequency significantly decreased from baseline to follow-up. Both at T1 and T2, seizure frequency was slightly, but significantly correlated with depression and anxiety levels (rs=0.17-.32). Cross-lagged-analyses showed that baseline (T1) level of depression significantly predicted frequency of seizures at follow-up (T2). However, anxiety at T1 was not a significant predictor of seizure frequency at T2 and seizure frequency at T1 did not predict either depressive or anxiety symptoms at T2. CONCLUSION: The present findings emphasize the importance of psychiatric comorbidities, especially depression, for seizure frequency and its progress in patients with difficult-to-treat epilepsies referred to a specialized epilepsy center. Thus, comorbid psychiatric disorders need specific consideration as part of a comprehensive diagnostic and therapeutic treatment approach.


Subject(s)
Anxiety Disorders/physiopathology , Depressive Disorder/physiopathology , Drug Resistant Epilepsy/physiopathology , Adolescent , Adult , Aged , Anxiety Disorders/epidemiology , Comorbidity , Depressive Disorder/epidemiology , Drug Resistant Epilepsy/epidemiology , Female , Follow-Up Studies , Humans , Male , Middle Aged , Young Adult
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