1.
Mov Disord
; 26(1): 187-8, 2011 Jan.
Article
in English
| MEDLINE
| ID: mdl-21322027
2.
J Neurol
; 254(5): 613-6, 2007 May.
Article
in English
| MEDLINE
| ID: mdl-17415511
ABSTRACT
Hyperechogenicity of the substantia nigra (SN) has been found to be a typical sign in idiopathic Parkinson's disease (PD), prevalent in more than 90% of affected individuals. To see whether SN hyperechogenicity is also characteristic for monogenetically caused PD, we investigated PD patients with alpha-synuclein, LRRK2, parkin, PINK1 and DJ-1 mutations by transcranial sonography (TCS). In all these patients the area of SN echogenicity was significantly larger than in healthy controls, but smaller, than in idiopathic PD. As SN hyperechogenicity could be related to an increased iron content of the SN, these findings suggest that iron may play a less significant role in the pathogenesis of monogenetically caused compared to idiopathic PD.
Subject(s)
Parkinson Disease/classification , Parkinson Disease/diagnostic imaging , Ultrasonography, Doppler, Transcranial/methods , Aged , Female , Humans , Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 , Male , Mutation , Parkinson Disease/genetics , Parkinson Disease/pathology , Protein Kinases/genetics , Protein Serine-Threonine Kinases/genetics , Substantia Nigra/diagnostic imaging , Substantia Nigra/pathology , Ubiquitin-Protein Ligases/genetics , alpha-Synuclein/genetics
3.
Brain
; 128(Pt 12): 3000-11, 2005 Dec.
Article
in English
| MEDLINE
| ID: mdl-16251215