1.
Sarcoidosis Vasc Diffuse Lung Dis
; 33(2): 182-5, 2016 Aug 01.
Article
in English
| MEDLINE
| ID: mdl-27537724
ABSTRACT
Pulmonary arterial hypertension is a progressive life-threatening disease characterized by vascular remodeling. There is evidence that varied immune mechanism play an important role in progression of pulmonary hypertension. We describe a case of a 35-year-old woman with idiopathic pulmonary arterial hypertension (IPAH) and a novel BMPR2 mutation, who underwent a successful lung transplantation. Extensive granulomatous inflammation was seen in the resected lungs. The granulomatous inflammation found in the histology supports a sarcoid-like reaction due to pulmonary hypertension in the context of the BMPR2 mutation.
Subject(s)
Bone Morphogenetic Protein Receptors, Type II/genetics , Familial Primary Pulmonary Hypertension/genetics , Mutation , Sarcoidosis, Pulmonary/etiology , Adult , Biopsy , Familial Primary Pulmonary Hypertension/complications , Familial Primary Pulmonary Hypertension/diagnosis , Familial Primary Pulmonary Hypertension/surgery , Female , Genetic Predisposition to Disease , Humans , Lung Transplantation , Sarcoidosis, Pulmonary/diagnosis
2.
Thorax
; 69(2): 193, 2014 Feb.
Article
in English
| MEDLINE
| ID: mdl-24186920
Subject(s)
Granuloma, Foreign-Body/diagnosis , Granuloma, Foreign-Body/etiology , Obsessive-Compulsive Disorder/complications , Pneumonia/diagnosis , Pneumonia/etiology , Adult , Biopsy , Cellulose/analysis , Diagnosis, Differential , Fatal Outcome , Female , Granuloma, Foreign-Body/pathology , Humans , Hygiene , Lung/pathology , Obsessive-Compulsive Disorder/diagnosis , Pneumonia/pathology , Tomography, X-Ray Computed
3.
J Hypertens
; 27(10): 2119-20; author reply 2120, 2009 Oct.
Article
in English
| MEDLINE
| ID: mdl-19893437
