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Virus Res ; 131(2): 224-32, 2008 Feb.
Article in English | MEDLINE | ID: mdl-17980926

ABSTRACT

We have conducted a large sequence study of the E1-E2 and NS5A regions of the HCV, subtypes 1a and b, both in patients previously treated with interferon, and untreated patients, who later responded, or not, to a combination therapy based on interferon plus ribavirin. We have examined the role played by the number of positively selected sites on disease progression and its relationship with several variables such as patients' age, sex and their risk of acquiring the disease. We have detected three groups of patients that respond or not to combination therapy: responders of intermediate age, older non-responders and young non-responders, they possess an increasing average number of positively selected sites in the E1-E2 region, respectively. We conclude that the host's genetic factors play an important role in whether the disease is contained or becomes chronic.


Subject(s)
Antiviral Agents/therapeutic use , Hepacivirus/drug effects , Hepatitis C/drug therapy , Hepatitis C/virology , Interferons/therapeutic use , Ribavirin/therapeutic use , Selection, Genetic , Adult , Aged , Amino Acid Sequence , Amino Acid Substitution , Female , Hepacivirus/genetics , Hepacivirus/isolation & purification , Humans , Male , Middle Aged , Molecular Sequence Data , RNA, Viral/genetics , Sequence Analysis, DNA , Treatment Outcome , Viral Envelope Proteins/genetics , Viral Nonstructural Proteins/genetics
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