ABSTRACT
Of 121 children vaccinated for measles in Zaïre, antibody studies revealed that 69% sero-converted. These included 53% of children vaccinated by two shots of a dermojet (0.2 ml i.d.) and 80% of children vaccinated by 0.5 ml subcutaneously. Whilst a dermojet gives less good results, a decision on its use needs to be made in each individual situation, particularly taking into account the quantity of vaccine available for the number of children presenting for vaccination. At six months of age 59% of children sero-converted. This did not reach 100% until 16 months of age. In view of the young age of children getting measles in Zaïre, there would seem to be value in vaccinating at six months, but this needs to be repeated at 16 months if full cover is required.
Subject(s)
Measles Vaccine/administration & dosage , Measles/prevention & control , Age Factors , Antibodies, Viral/analysis , Child, Preschool , Democratic Republic of the Congo , Humans , Infant , Injections, Jet , Injections, Subcutaneous , Measles virus/immunologySubject(s)
Costs and Cost Analysis , Injections, Intradermal/instrumentation , Measles Vaccine/administration & dosage , Measles/prevention & control , Vaccination/methods , Developing Countries , Dose-Response Relationship, Drug , Humans , Infant , Injections, Jet/instrumentation , Measles virus/immunology , Public Health , Vaccination/instrumentation , Vaccination/standardsSubject(s)
Infant, Newborn, Diseases/prevention & control , Tetanus/prevention & control , Adjuvants, Immunologic/administration & dosage , Adsorption , Antibodies/analysis , Antibody Formation , Developing Countries , Female , Gestational Age , Humans , Immunization Schedule , Infant , Infant, Newborn , Maternal-Fetal Exchange , Pregnancy , Tetanus Toxoid/administration & dosage , Tetanus Toxoid/adverse effects , Time FactorsABSTRACT
An intradermal jet injector was used to administer combined diphtheria, tetanus, and pertussis (D.T.P.) vaccines to infants aged 2 to 12 months. A second dose was given one month after the first and a third six months after the second. Each dose was considerably smaller than the standard intramuscular dose. Blood samples taken one month after the third dose showed a satisfactory diphtheria and tetanus antitoxin response in all but a few cases. The antibody response to the pertussis component was not examined. Reactions were insignificant. Intradermal jet injection is proposed as a cheap, extremely rapid, and effective technique for D.T.P. immunization, especially suitable for use in remote areas where trained staff and facilities are few and many children require immunization.
