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1.
Single-cell genomics illuminates human forebrain development.
Bradley, Conor A.
Nat Rev Genet ; 21(1): 2-3, 2020 01.
Article in English | MEDLINE | ID: mdl-31641219

Subject(s)
Genomics , Organoids , Humans , Prosencephalon
2.
A statistical framework for rare disease diagnosis.
Bradley, Conor A.
Nat Rev Genet ; 21(1): 2-3, 2020 01.
Article in English | MEDLINE | ID: mdl-31676876

Subject(s)
Gene Expression Profiling , Rare Diseases , DNA Mutational Analysis , Genetic Predisposition to Disease , Humans
3.
PRC2-mediated MHC-I silencing drives immune evasion.
Bradley, Conor A.
Nat Rev Cancer ; 19(12): 664, 2019 12.
Article in English | MEDLINE | ID: mdl-31616077

Subject(s)
Immune Evasion , Neoplasms , Antigen Presentation , Histocompatibility Antigens Class I , Humans
4.
CD24 - a novel 'don't eat me' signal.
Bradley, Conor A.
Nat Rev Drug Discov ; 18(10): 747, 2019 09.
Article in English | MEDLINE | ID: mdl-31570841

Subject(s)
Macrophages , Neoplasms , CD24 Antigen , Humans , Immunotherapy , Signal Transduction
5.
Tumour microbiome defines outcomes.
Bradley, Conor A.
Nat Rev Gastroenterol Hepatol ; 16(11): 649, 2019 11.
Article in English | MEDLINE | ID: mdl-31477872

Subject(s)
Gastrointestinal Microbiome , Microbiota , Pancreatic Neoplasms , Humans
6.
In vivo T cell CRISPR screens reveal immunotherapeutic targets.
Bradley, Conor A.
Nat Rev Cancer ; 19(11): 606, 2019 11.
Article in English | MEDLINE | ID: mdl-31492928

Subject(s)
Clustered Regularly Interspaced Short Palindromic Repeats , Genome , CD8-Positive T-Lymphocytes , CRISPR-Cas Systems , Humans , Immunotherapy
7.
Tumour microbiome defines outcomes.
Bradley, Conor A.
Nat Rev Cancer ; 19(10): 545, 2019 10.
Article in English | MEDLINE | ID: mdl-31471581

Subject(s)
Microbiota , Pancreatic Neoplasms , Humans
8.
CD24 - a novel 'don't eat me' signal.
Bradley, Conor A.
Nat Rev Cancer ; 19(10): 541, 2019 10.
Article in English | MEDLINE | ID: mdl-31406301

Subject(s)
Neoplasms , CD24 Antigen , Humans , Immunotherapy , Macrophages , Signal Transduction
9.
SCNC phenotypic convergence reveals shared vulnerabilities.
Bradley, Conor A.
Nat Rev Cancer ; 19(10): 543, 2019 10.
Article in English | MEDLINE | ID: mdl-31371791

Subject(s)
Hematologic Neoplasms , Neoplasms , Humans
10.
Guiding pancreatic cyst management.
Bradley, Conor A.
Nat Rev Gastroenterol Hepatol ; 16(10): 582-583, 2019 10.
Article in English | MEDLINE | ID: mdl-31409907

Subject(s)
Pancreatic Cyst , Pancreatic Neoplasms , Humans , Multimodal Imaging
11.
Challenging (immunogenically) silent assumptions.
Bradley, Conor A.
Nat Rev Cancer ; 19(9): 483, 2019 09.
Article in English | MEDLINE | ID: mdl-31316158

Subject(s)
CD8-Positive T-Lymphocytes , Precursor Cell Lymphoblastic Leukemia-Lymphoma , Child , Humans
12.
Prophylactic TNF blockade reduces autoimmune toxicity.
Bradley, Conor A.
Nat Rev Drug Discov ; 18(7): 500, 2019 Jul.
Article in English | MEDLINE | ID: mdl-31267071
13.
Opening up a pathway for disease modification in osteoarthritis.
Bradley, Conor A.
Nat Rev Drug Discov ; 18(7): 497, 2019 Jul.
Article in English | MEDLINE | ID: mdl-31267074
14.
TCR-grafted T cells restore antiviral immunity.
Bradley, Conor A.
Nat Rev Gastroenterol Hepatol ; 16(8): 454-455, 2019 08.
Article in English | MEDLINE | ID: mdl-31239551

Subject(s)
Antiviral Agents , Hepatitis B , Hepatitis B virus , Humans , Receptors, Antigen, T-Cell , T-Lymphocytes
15.
Glutamine-fuelled OXPHOS - a new target in MCL.
Bradley, Conor A.
Nat Rev Cancer ; 19(7): 363, 2019 07.
Article in English | MEDLINE | ID: mdl-31148591

Subject(s)
Glutamine , Humans
16.
Prophylactic TNF blockade reduces autoimmune toxicity.
Bradley, Conor A.
Nat Rev Cancer ; 19(7): 364, 2019 07.
Article in English | MEDLINE | ID: mdl-31073225
17.
Prophylactic TNF blockade reduces autoimmune toxicity.
Bradley, Conor A.
Nat Rev Clin Oncol ; 16(8): 464, 2019 08.
Article in English | MEDLINE | ID: mdl-31086280

Subject(s)
Immunotherapy , Programmed Cell Death 1 Receptor , CTLA-4 Antigen , Humans , Immunologic Factors
18.
68Ga-PSMA-11 PET enables accurate detection of recurrent disease.
Bradley, Conor A.
Nat Rev Urol ; 16(7): 388, 2019 07.
Article in English | MEDLINE | ID: mdl-30971764

Subject(s)
Prostatic Neoplasms , Edetic Acid , Gallium Isotopes , Gallium Radioisotopes , Humans , Male , Membrane Glycoproteins , Organometallic Compounds , Positron-Emission Tomography , Prospective Studies
19.
Brain metastases respond to neratinib plus capecitabine.
Bradley, Conor A.
Nat Rev Clin Oncol ; 16(6): 336, 2019 06.
Article in English | MEDLINE | ID: mdl-30940923

Subject(s)
Brain Neoplasms/secondary , Breast Neoplasms , Capecitabine , Humans , Quinolines , Receptor, ErbB-2
20.
Pembrolizumab improves OS across PD-L1 subgroups.
Bradley, Conor A.
Nat Rev Clin Oncol ; 16(7): 403, 2019 07.
Article in English | MEDLINE | ID: mdl-30992570

Subject(s)
Carcinoma, Non-Small-Cell Lung , Lung Neoplasms , Antibodies, Monoclonal, Humanized , B7-H1 Antigen , Humans
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