1.
Exp Neurol
; 170(2): 375-9, 2001 Aug.
Article
in English
| MEDLINE
| ID: mdl-11476604
ABSTRACT
Cerebellar Purkinje cells degenerate in shaker mutant rats. Glia cell line-derived neurotrophic factor (GDNF) was chronically infused intraventricularly in an attempt to rescue mutant Purkinje cells from dying. Four weeks of chronic GDNF infusion delayed the degeneration of many but not all Purkinje cells. Surviving Purkinje cells formed spatially related groups interrupted by other groups of degenerated Purkinje cells. There was a positive correlation in GDNF-supported Purkinje cell survival and persistence of normal motor behaviors.
Subject(s)
Cell Survival/drug effects , Cerebellum/drug effects , Cerebral Ventricles/physiology , Nerve Degeneration/prevention & control , Nerve Growth Factors , Nerve Tissue Proteins/pharmacology , Purkinje Cells/drug effects , Animals , Cerebellum/cytology , Cerebellum/physiology , Cerebral Ventricles/drug effects , Glial Cell Line-Derived Neurotrophic Factor , Infusions, Parenteral , Nerve Tissue Proteins/administration & dosage , Purkinje Cells/cytology , Purkinje Cells/physiology , Rats , Rats, Mutant Strains , Rats, Wistar
2.
Indiana Med
; 79(10): 859-61, 1986 Oct.
Article
in English
| MEDLINE
| ID: mdl-3782767
3.
Indiana Med
; 79(1): 24-6, 1986 Jan.
Article
in English
| MEDLINE
| ID: mdl-3950368