Finding of increased caudate nucleus in patients with Alzheimer's disease.

OBJECTIVES: A recently published study using an automated MRI volumetry method (NeuroQuant®) unexpectedly demonstrated larger caudate nucleus volume in patients with Alzheimer's disease dementia (AD) compared to patients with subjective and mild cognitive impairment (SCI and MCI). The aim of this study was to explore this finding. MATERIALS & METHODS: The caudate nucleus and the hippocampus volumes were measured (both expressed as ratios of intracranial volume) in a total of 257 patients with SCI and MCI according to the Winblad criteria and AD according to ICD-10 criteria. Demographic data, cognitive measures, and APOE-ɛ4 status were collected. RESULTS: Compared with non-dementia patients (SCI and MCI), AD patients were older, more of them were female, and they had a larger caudate nucleus volume and smaller hippocampus volume (P<.001). In multiple linear regression analysis, age and female sex were associated with larger caudate nucleus volume, but neither diagnosis nor memory function was. Age, gender, and memory function were associated with hippocampus volume, and age and memory function were associated with caudate nucleus/hippocampus ratio. CONCLUSIONS: A larger caudate nucleus volume in AD patients was partly explained by older age and being female. These results are further discussed in the context of (1) the caudate nucleus possibly serving as a mechanism for temporary compensation; (2) methodological properties of automated volumetry of this brain region; and (3) neuropathological alterations. Further studies are needed to fully understand the role of the caudate nucleus in AD.

Social and depressive stress suffered by spouses of patients with mild dementia.

OBJECTIVE: To identify stressors and their correlates in spouses of patients with mild dementia. DESIGN: Retrospective study of patient records. SETTING: Patients attending a Memory Clinic at Ullevaal Hospital in Oslo. SUBJECTS: 92 mildly demented patients living at home (mean age 75.7 years, 51% women, mean MMSE score 22.3) and their spouses. MAIN OUTCOME MEASURES: Frequency and types of stress suffered by spouses using validated and factor-analyzed instruments as measures. RESULTS: Twenty-five per cent or more of the spouses reported often/always having problems with the following: being depressed by the situation, having difficulties getting away on holiday, social life being affected, household routines being upset, and sleep being interrupted. Factor analysis of the Greene Caregiver Stress Scale (15 items) identified two factors; 'Social stress' and 'Depressive stress'. Social stress was associated with the patient's I-ADL level, and depressive stress with mood and behaviour of the patient. The depressive symptomatology of the patient as expressed by the spouses was related to both depressive and social stress, whereas cognitive function, as measured by the MMSE, was not an independent predictor of carer strain. CONCLUSION: Even in mildly demented patients, symptoms of carer stress are frequent. Supportive strategies such as early diagnosis, information for carers and intervention strategies are discussed.

Dementia and driving: an attempt at consensus.

The number of older drivers in Sweden will be rapidly increasing during the next decades. A possible relationship exists between the increased relative crash risk of older drivers and the prevalence of age-related diseases such as dementia. However, a clear-cut policy for evaluating driving competence in demented persons is still lacking. In recognition of this fact, the Swedish National Road Administration invited a group of researchers to formulate a consensus on the issue of driving and dementia. This consensus document is aimed at providing primary care physicians with practical advice concerning the assessment of cognitive status in relation to driving. Suggestions are based on a review of existing research and discuss the use of general and driving-specific sources of information available to the physician. Consensus was reached on the statement that a diagnosis of moderate to severe dementia precludes driving and that certain individuals with mild dementia should be considered for a specialized assessment of their driving competence.

[Memory clinic--ambulatory examination in suspected dementia]. / Hukommelsesklinikk--poliklinisk utredning ved mistanke om demens.

Dementia and confusion are frequently overlooked by general practitioners. A memory clinic was established at the Department of Geriatric Medicine, Ullevål Hospital in September 1990 with the intention of creating a standardized programme for diagnosing dementia and cognitive impairment in the elderly in an out-patient setting. The activities and services offered by the clinic are described: diagnoses, information to patients, their family and staff in the primary health care system about the symptoms and treatment of dementia. In addition, advice is given on follow-up care and how to apply for care through the national health service. There has been a great demand for the services of the Memory Clinic, and we believe that the methods used are adequate in an out-patient setting. The concept could easily be transferred to other specialist clinics involved with the elderly, and parts of the programme could also be used by general practitioners.

[Aging, dementia and automobile driving]. / Aldring, demens og bilkjøring.

According to Norwegian law, drivers 70 years and older must carry a health certificate. This is issued by a general practitioner. If the patient is not supposed to drive because of a medical condition, the doctor should report this to the County Health Officer. This can be problematic, not only because assessing whether a patient fulfills the criteria for driving is difficult, but also because the doctor has obligations to both the public and his patient. These problems are discussed, based on assessment of available literature and on personal experience. Dementia is common in old age and affects approximately 15% of persons aged 75 and older. Patients with moderate and severe dementia should certainly not drive. However, some patients with mild dementia can nevertheless be safe drivers. The problem, however, is to identify the safe drivers among patients with mild dementia. The current regulations on dementia and driving are presented briefly.

Mental impairment and driving licences for elderly people--a survey among Norwegian general practitioners.

OBJECTIVE: Study how GPs assess mental function when a health certificate for elderly drivers has to be issued. DESIGN: Postal questionnaire survey. SETTING: Nationwide survey. SUBJECTS: Random sample of 532 Norwegian general practitioners, response rate 54%. MAIN OUTCOME MEASURES: Open and closed questions. RESULTS: Various types of examinations and assessments are carried out in this context. More than 50% always assess mental function. Only 22% use formal mental tests, mostly when in doubt. The assessment of elderly patients for a health certificate for driving is regarded by many as a difficult problem. CONCLUSION: There is a lack of uniformity in issuing a health certificate to elderly drivers, a low use of formal cognitive testing, and problems facing GPs in this context. More concrete guidelines and a formal second-line system would facilitate an objective assessment and could also alleviate the burden on the doctor.

The set test as a diagnostic tool in elderly outpatients with suspected dementia.

The set test was validated in 138 outpatients (mean age 74 years, 65% women) against a global clinical assessment using the DSM-III-R criteria for dementia. The test proved to have low sensitivity even at cutpoints close to a full score, and 12 of 72 patients diagnosed with dementia had a full score. We were unable to confirm the hypothesis that the set test can distinguish between vascular and Alzheimer's type of dementia. Used in its original form, the set test does not seem to be an appropriate diagnostic tool in the setting of a memory clinic.

A low, 'normal' score on the Mini-Mental State Examination predicts development of dementia after three years.

OBJECTIVES: To study whether a low, "normal" sumscore (i.e., 24 or higher) on the Mini-Mental Status Examination (MMSE) near the cutpoint usually employed for identifying persons with cognitive impairment predicts later development of dementia. DESIGN: A prospective study of a random sample of nondemented persons aged 75 years and older, according to DSM-III criteria, with follow-ups after 3 and 6 years. PARTICIPANTS: The subjects were 215 persons living at home, mean age 81 years, 81% women. Their mean MMSE sumscore at the start of the study (T0) was 27.9 (range 24-30). MAIN RESULTS: A low MMSE sumscore at T0 was identified as a statistically strongly significant predictor of dementia after 3 years (P < .001), when more than 40% of those with a sumscore of 24 or 25 at T0 had become demented. A similar, although weaker and statistically nonsignificant, trend was observed for the risk after 6 years in relation to MMSE scoring at baseline. CONCLUSION: Persons with a sumscore of 24 or 25 and classified as not suffering from dementia according to the DSM-III criteria are at high risk of developing dementia within 3 years.

[Delirium (acute confusion) among elderly patients after admission to a medical department]. / Delirium (akutt konfusjon) hos gamle pasienter ved innleggelse i medisinsk avdeling.

Delirium is a common mental disorder among the elderly. In this study we examined the prevalence of delirium among patients older than 75 years of age who had been admitted to an acute medical ward. 14 of 58 patients (24%) received a diagnosis of delirium. For these patients we recorded in all 58 factors possibly associated with its occurrence, four on average per patient. Drugs, cerebrovascular disease, and congestive heart failure were the most common factors. The large number of possibly contributing factors precludes a definite conclusion regarding precipitating factors. Mini-Mental State Examination, which is a commonly used screening-instrument for detecting cognitive impairment, was of minor value in detecting delirium.

The Mini-Mental State Examination: identifying the most efficient variables for detecting cognitive impairment in the elderly.

OBJECTIVES: To study how well the scoring on each item of the MMSE relates to the sum-score when the purpose is to identify persons with cognitive impairment, and to identify an equally effective subset of MMSE items for predicting cognitive impairment. DESIGN: Retrospective survey of MMSE data for 850 elderly. SETTING: A variety of clinical settings. PARTICIPANTS: Mean age 82 years (range 54 to 99), 74% women. The subjects were of three different categories: geriatric in-patients, patients living under supervision, and elderly people living independently at home. RESULTS: Five of the binomial ("State," "Town," "Name a pencil," "Name a watch," "Read and obey") and one of the polychotomous MMSE variables ("Learn three words and repeat immediately") had low sensitivity and gave high percentages of misclassifications versus the sumscore dichotomized at the cut-point 23/24. Univariate logistic regression indicated that the three remaining polychotomous variables ("Spell backwards," "Recall three words," and "Three-stage command") can be scored binomially. Two factors were identified on factor analysis. Logistic regression analysis showed that 12 of the original 20 items predicted the sumscore dichotomized at 23/24 with only 3% misclassifications. Validation against the psychogeriatrician's diagnosis showed that this 12-items MMSE derivative performs as well as the full MMSE. CONCLUSIONS: Six of the 20 MMSE variables perform poorly regarding sensitivity and misclassifications versus the sumscore at cut-point 23/24. Two additional items did not contribute to the prediction of a low/high sumscore. The remaining 12 MMSE items can all be scored binomially and produce a sumscore which is equally as effective as the sumscore of the full MMSE when the purpose is to identify elderly patients with cognitive impairment.