Measurement of the Pion Form Factor with CMD-3 Detector and Its Implication to the Hadronic Contribution to Muon (g-2).

The cross section of the process e^{+}e^{-}→π^{+}π^{-} has been measured in the center-of-mass energy range from 0.32 to 1.2 GeV with the CMD-3 detector at the electron-positron collider VEPP-2000. The measurement is based on an integrated luminosity of about 88 pb^{-1}, of which 62 pb^{-1} represent a complete dataset collected by CMD-3 at center-of-mass energies below 1 GeV. In the dominant region near the ρ resonance a systematic uncertainty of 0.7% was achieved. The implications of the presented results for the evaluation of the hadronic contribution to the anomalous magnetic moment of the muon are discussed.

[Interstrain differences in social and time patterns of agonistic behavior in male laboratory mice].

The aim of present study was to reveal the genetic effects on social dominance and patterns of agonistic behaviors in social partners. The study was carried out in adult male mice of three inbred strains BALB/cLac, CBA/Lac and PT using an ethological model of social hierarchy, which is characterised by the minimal size and genetic heterogeneity (two males of different genotypes). We used a neutral territory as the experimental territorial condition for the establishment of social hierarchy. Rank asymmetry in aggressive and defensive behaviors was quickly formed during the first day after the production of the social. Significant interstrain differences in time patterns ofagonistic behavior in dominants and subordinates as well as in the level of social dominance determined as a proportion of dominant animals in the strain were observed. In was shown that, in laboratory mice, the genotype could markedly influence social dominance and the patterns of agonistic behavior in social partners.

[Maturation of sexual behavior in laboratory male mice: a role of genotype].

Sexual behaviour and testosterone output in response to a receptive female were investigated in male mice of three inbred strains BALB/cLac, CBA/Lac and PT at puberty (45 days of age) and in adulthood (90 days of age). The animals were exposed for 10 min to a receptive female separated by a plastic grill, which would not allow contact between male and female. Male and female behaviour was recorded by measuring the time the male or female spent at the grill and the number of approaches to it (sexual motivation). The grill was then removed and the number of mounts and chemoinvestigatory behavior towards a female (nasal and anogenital sniffing) was recorded for each male. An increase in serum concentration and testicular content of testosterone was used as an endocrine index of the sensitivity to female pheromones. It has been shown the significant genotype and developmental effects on sexual behaviour and the hormonal response to sexual stimuli. The pubertal BALB/cLac males were characterised by the adult pattern of sexual motivation, chemoinvestigatory behaviour and the evident testosterone respond to a female. Males of the strain PT showed the lowest sexual motivation, chemoinvestigatory behavior towards a receptive female and no testosterone responses at both ages. This is a very different situation with the CBA/Lac's who showed the developmental increase in the sexual motivation, sniffing behaviour and the endocrine reflex, and the highest level of sexual behaviour but the moderate testosterone respond to a female at adulthood. The data obtained suggest genotype related asynchrony in maturation of the olfactory system, pituitary-gonadal axis and neural circuits of sexual behavior, and their independent genetic control. So, the set of mice strains investigated represents a useful tool for genetic and endocrine study of sexual behavior and the chemosensory control of testicular steroidogenesis.

[Individual typological peculiarities of system blood flow, physical capacity for work and cardiac activity regulation in patients with different resistance to periodontal diseases].

From position of typological variability of physiological individuality concept-functional constitution types - the principle of organism integrity was substantiated for stomatological pathology. There were isolated typical and specific reactions of cardiac-vessel system in patients with different resistance to periodontal diseases. Each functional type - patients with different levels of usual motion activity - had their own physiological peculiarities of parameters of system blood flow, physical capacity for work and cardiac activity regulation, that determined individual typological organism reaction in cases of maxillo-facial system pathology. The received data gives the objective base for physiological approach to single out the extreme variants of norm for forming risk contingent and groups of resistant people to periodontal diseases.

[The reproductive correlates of social hierarchy in laboratory male mice].

In laboratory male mice the effects of social hierarchy on hormonal and spermatogenic testicular function, accessory organs and testicular weights, sexual behaviour have been investigated using an experimental model of social hierarchy, which is characterised by a minimal size (two male mice) and 5 days period of social interactions. The social rank of the partners was detected by asymmetry in aggressive behaviour. Using the experimental condition, when the both partners have no preferences for exclusive use of area we demonstrated that there were no rank differences in the number of mounts and testicular testosterone content. Nevertheless a rank asymmetry in the male sniffing behaviour towards a receptive female, weights of the testes, seminal vesicles, epididymes and the number of epididymal sperm was kept up in a stable social group. Social dominance was found to affect negatively on testicular testosterone increase in response to introduction of a receptive female and sexual attractiveness of male to a receptive female in both dominant and subordinate males. The results obtained demonstrate the impact of social hierarchy on reproduction in laboratory male mice, particular in respect of spermatogenesis and the testicular testosterone in response to a receptive female.

[Competition for limited environmental resources on the social dominance model in laboratory mice].

Asymmetry of social rank in the competition for food and female was studied using the social dominance model with only two male mice. Marking activity was recorded as a useful indicator of the social status. Social rank was determined by asymmetry in aggressive behavior. A food test was presented for 10 min daily within 5 days of the experiment, whereas a sexual test was performed only on the 5th day for 30 min. Marking behavior was estimated twice: before the first interaction and on the 4th day of the experiment. The competition for food was accompanied by active attacks, escapes, vertical defense postures, and sniffing. The level of aggression, sniffing, and food activity was higher in dominant than submissive males. Time course of aggressive, defensive, and sniffing behaviors was characterized by maximum scores in the period of formation of social hierarchy; however, the rate of food activity in this period was low and increased only to the 4th day. Introduction of a receptive female into the male group with the stable social hierarchy stimulated the intermale aggression, defensive and sniffing behaviors. Dominant males were characterized by a greater number of victories over and sniffing contacts with both male and female. Marking activity was also more intense in dominants. Thus, significant unidirectional rank differences in agonistic, sniffing, food, sexual, and marking behaviors were shown on the social dominance model with the minimum number of partners.

[The experimental model of establishment and maintenance of social hierarchy in laboratory mice].

The goal of the investigation is to establish a new experimental model of social hierarchy in laboratory mice. The important feature of the model is a group of two males only placed into the special experimental cage. The cage consists of two nestling chambers and central chamber. Observations were made 3 times per day (20 min each) throughout 5 days. Aggression, defence and sniffing behaviours of both partners were recorded during each observation period using video camera. Social rank was detected by asymmetry in aggressive behaviour. It was shown that social hierarchy was established during the first four tests limited by the first 24 h after pairing. After this period aggression and defence behaviours were greatly decreased. After the first 5 tests a stabilization in aggression (number of wins, active attacks and not direct aggression) and defence (number of vertical defensive postures and escapes) as well as sniffing behaviours took place. But a strong asymmetry in mentioned here behaviours in males of different ranks (dominants and subordinates) was kept up. Thus we offer a new experimental model of minimal society, which entirely reproduces a pattern of establishment and maintenance of social hierarchy. Our model demonstrates significant differences in agonistic, defence and sniffing behaviours between males of different social rank.