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1.
Ter Arkh ; 93(9): 1125-1131, 2021 Sep 15.
Article in Russian | MEDLINE | ID: mdl-36286874

ABSTRACT

Results of foreign and Russian studies indicate a higher mortality rate of patients with concomitant cardiovascular diseases (CVD) due to the new coronavirus infection COVID-19. It has been proven that arterial hypertension, as one of the significant risk factors for the development of concomitant cardiovascular diseases, is associated with a more severe prognosis of COVID-19. This article presents the results of modern studies and large meta-analyzes of necessity and safety of the use of blockers of the renin-angiotensin-aldosterone system in patients with arterial hypertension and COVID-19. The data of studies show that an angiotensin-converting enzyme inhibitor (ACE inhibitor) and a thiazide-like diuretic is a pathogenetically rational combination. It realizes various ways of lowering blood pressure by reducing the activity of the renin-angiotensin-aldosterone system, which is achieved by using an ACE inhibitor, and natriuresis due to diuretics. As an example, a highly effective fixed combination of drugs is considered, characterized by good tolerance, which consists of an ACE inhibitor lisinopril and a thiazide-like diuretic indapamide of prolonged action. The authors expressed the opinion that the appointment of the fixed combination drug Diroton Plus (Gedeon Richter) will contribute to effective control of blood pressure and organoprotection in conditions of increased thrombogenic and prooxidative potential, characteristic of COVID-19 both in the acute stage and within the post-COVID Syndrome.


Subject(s)
COVID-19 Drug Treatment , Cardiovascular Diseases , Hypertension , Indapamide , Humans , Antihypertensive Agents/adverse effects , Indapamide/adverse effects , Lisinopril , Cardiovascular Diseases/drug therapy , Pandemics , Hypertension/drug therapy , Hypertension/epidemiology , Hypertension/complications , Angiotensin-Converting Enzyme Inhibitors/pharmacology , Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Diuretics/therapeutic use , Thiazides/therapeutic use
4.
Kardiologiia ; 24(4): 9-13, 1984 Apr.
Article in Russian | MEDLINE | ID: mdl-6727119

ABSTRACT

Sixty-nine coronary heart disease patients with stable angina of effort of Classes II-IV of functional activity were studied for the effect of three nonselective beta-adrenergic blockers on the incidence and intensity of angina attacks, on the tolerance to exercise on the bicycle ergometer, as well as on the heart rate, arterial pressure, cardiac volumes and intracardiac hemodynamics using a complex of clinical and instrumental methods. It was proved that nadolol, pindolol and propranolol hydrochloride possessed similar anti-anginal effects but nadolol exerted the greatest negative chronotropic action while propranolol hydrochloride exerted a negative inotropic action. As regards the degree of the effect on cardiac volumes, corgard (nadolol) occupied an intermediate position between anaprilin (propranolol hydrochloride) and visken (pindolol).


Subject(s)
Angina Pectoris/drug therapy , Pindolol/therapeutic use , Propanolamines/therapeutic use , Propranolol/therapeutic use , Adult , Aged , Angina Pectoris/physiopathology , Exercise Test , Female , Hemodynamics , Humans , Kinetics , Male , Middle Aged , Myocardial Contraction , Nadolol , Propanolamines/adverse effects
8.
Kardiologiia ; 20(12): 21-5, 1980 Dec.
Article in Russian | MEDLINE | ID: mdl-6782320

ABSTRACT

On the basis of clinical examination and the results of bicycle ergometry and echocardiography in 58 patients with chronic ischemic heart disease the authors determined the contingent of patients in whom long-acting nitrates were most effective. The high clinical effectiveness of the agents in patients with symptoms of the initial stage of cardiac insufficiency is proved and the absence of any essential differences between long-acting nitrates in the character of their effect on hemodynamics is shown. It is established that nitroglycerin and long-acting nitrates cause a qualitatively similar effect on myocardial contractile function and intracardiac hemodynamics in patients with ischemic heart disease.


Subject(s)
Cardiovascular Agents , Nitro Compounds/therapeutic use , Adult , Aged , Angina Pectoris/drug therapy , Chronic Disease , Coronary Disease/drug therapy , Delayed-Action Preparations , Drug Evaluation , Female , Hemodynamics/drug effects , Humans , Male , Middle Aged , Nitrates/therapeutic use , Nitroglycerin/therapeutic use
12.
Kardiologiia ; 19(4): 26-30, 1979 Apr.
Article in Russian | MEDLINE | ID: mdl-35643

ABSTRACT

The article discusses the results of dynamic echocardiographic examination of 46 patients with chronic ischemic heart disease before and after 15-day treatment with agents capable of blocking beta-receptors: propranolol (anaprilin), pindolol (visken), talinolol (cordan) which were prescribed in mean therapeutical doses. It is shown that agents blocking beta-adrenergic receptors lead to regular decrease in the indices of myocardial contractility. The character of changes in the volumetric characteristics of the left ventricle depends on the initial levels of arterial pressure and the degree of its dynamics during treatment with beta-adrenergic blocking agents. In patients with chronic ischemic heart disease developing against the background of hypertensive disease the dynamics of changes in the volumetric indices depends on the degree of arterial pressure reduction.


Subject(s)
Adrenergic beta-Antagonists/therapeutic use , Coronary Disease/physiopathology , Echocardiography , Myocardial Contraction/drug effects , Adult , Aged , Cardiac Volume/drug effects , Chronic Disease , Coronary Disease/drug therapy , Diastole/drug effects , Female , Heart Ventricles/drug effects , Humans , Male , Middle Aged , Systole/drug effects , Time Factors
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