ABSTRACT
The efficacy, tolerability and safety of low doses (5-7 mg/kg/day) of oral ciclosporin (CS) for treatment of endogenous uveitis resistant to conventional therapy were studied in an open, noncontrolled, multicenter long-term trial. CS was shown to be effective for patients with posterior or intermediate noninfectious uveitis; it limited the progression of the disease, decreased the number and severity of inflammatory relapses, and improved visual acuity while reducing signs of intraocular inflammation. Moreover, in corticodependent patients, a steroid-sparing effect was also obtained. At low doses and by means of the careful monitoring of safety parameters, the side effects (especially renal function impairment) were well controlled. Efficacy was maintained during long-term treatment.
Subject(s)
Cyclosporine/administration & dosage , Uveitis/drug therapy , Adult , Creatinine/blood , Cyclosporine/adverse effects , Dose-Response Relationship, Drug , Female , Follow-Up Studies , Humans , Long-Term Care , Male , Middle Aged , Visual Acuity/drug effectsABSTRACT
The authors examined 84 patients with pulmonary TBC treated with ethambutol (25 mg/Kg/die). The patients were divided into two groups on the basis of zinc plasma levels: 53 patients with zinc plasma level greater than 1 mg/l and 31 with zinc plasma levels less than 0.7 mg/l. The two groups underwent periodical follow-up of visual acuity, fundus, color vision (Fransworth 100 HUE) and visual field. The checks were monthly on the first group and fortnightly in the second. Eight patients presented signs of optic neuropathy. Patients with lower zinc plasma levels showed a higher percentage of optic neuropathy.
Subject(s)
Ethambutol/adverse effects , Optic Nerve Diseases/chemically induced , Adolescent , Adult , Child , Color Perception , Humans , Tuberculosis, Pulmonary/drug therapy , Visual Acuity , Visual Fields , Zinc/bloodABSTRACT
The AA. examined 36 uncomplicated ON (Optic neuritis) observed from 1-1-1970 to 31-12-1980. An ophthalmological, neurological, and electrophysiological test (VEP, SEP, BAER) is made on this patients from 1-1-1986 to 31-3-1986. The importance of the electrophysiological examination is evaluated to recognize subclinical Multiple Sclerosis.
Subject(s)
Evoked Potentials, Auditory , Evoked Potentials, Somatosensory , Evoked Potentials, Visual , Multiple Sclerosis/diagnosis , Optic Neuritis/physiopathology , Adolescent , Adult , Child , Female , Humans , Male , Middle Aged , Optic Neuritis/complications , Time FactorsABSTRACT
Restriction enzyme analysis was utilized to investigate 11 HSV isolates from patients with herpetic keratitis. The electrophoretic profiles of the DNAs indicate that the isolates belong to HSV-1 and are epidemiologically unrelated. Two of the isolates, derived from a patient with simultaneous bilateral herpetic keratitis were further characterized by genetic and phenotypic analyses. These studies showed the following: (i) the two recrudescent lesions were caused by the same HSV-1 isolate; (ii) the isolate yielded two different plaque phenotypes; (iii) these plaques showed different sensitivity to I.D.U.
