Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 6 de 6
Filter
1.
Dig Dis Sci ; 68(4): 1525-1528, 2023 04.
Article in English | MEDLINE | ID: mdl-36315333

ABSTRACT

Germline DNA alterations affecting homologous recombination pathway genes have been associated with pancreatic cancer (PC) risk. BRCA2 is the most studied gene and affects the management of PC patients and their families. Even though recent reports have suggested a similar role of germline ATM pathogenic variants (PV) in familial PC, there is still a disagreement between experts on how it could affect patient management given the lack of proper PC risk estimates. We retrospectively analyzed the germline data of 257 PC patients among whom nearly 50% were sporadic cases. We showed similar frequencies of BRCA2 (4.9%) and ATM (4.4%) PV or likely pathogenic variants, which were not related to familial history. Based on our findings and that of the literature, we suggest including ATM gene among the panel of genes analyzed in PC patients pending the publication of prospective studies.


Subject(s)
Genetic Predisposition to Disease , Pancreatic Neoplasms , Humans , Retrospective Studies , Prospective Studies , Germ-Line Mutation , Pancreatic Neoplasms/genetics , Pancreatic Neoplasms/pathology
3.
Diagn Interv Imaging ; 95(11): 1123-1125, 2014 11.
Article in English | MEDLINE | ID: mdl-25443336
4.
J Am Coll Cardiol ; 32(3): 794-9, 1998 Sep.
Article in English | MEDLINE | ID: mdl-9741529

ABSTRACT

OBJECTIVES: This study was undertaken to validate the in vivo intravascular ultrasound (IVUS) measurement of in-stent neointimal hyperplasia (IH) volumes. BACKGROUND: Because stents reduce restenosis compared to balloon angioplasty, stent use has increased significantly. As a result, in-stent restenosis is now an important clinical problem. Serial IVUS studies have shown that in-stent restenosis is secondary to intimal hyperplasia. To evaluate strategies to reduce in-stent restenosis, accurate measurement of in-stent neointimal tissue is important. METHODS: Using a porcine coronary artery model of in-stent restenosis, single Palmaz-Schatz stents were implanted into 16 animals with a stent:artery ratio of 1.3:1. Intravascular ultrasound imaging was performed at 1 month, immediately prior to animal sacrifice. In vivo IVUS and ex vivo histomorphometric measurements included stent, lumen and IH areas; IH volumes were calculated with Simpson's rule. RESULTS: Intravascular ultrasound measurements of IH (30.4+/-11.0 mm3) volumes correlated strongly with histomorphometric measurements (26.7+/-8.5 mm3, r=0.965, p < 0.0001). The difference between the IVUS and the histomorphometric measurements of IVUS volume was 4.1+/-2.7 mm3 or 15.8+/-11% (standard error of the estimate=0.7). Both histomorphometry and IVUS showed that IH was concentric and uniformly distributed over the length of the stent. Intravascular ultrasound detected neointimal thickening of < or =0.2 mm in 5 of 16 stents. Sample size calculations based on the IVUS measurement of IH volumes showed that 12 stented lesions/arm would be required to show a 50% reduction in IVUS-measured IH volume and 44 stented lesions/arm would be required to show a 25% reduction in IH volume. CONCLUSION: In vivo IVUS measurement of IH volumes correlated strongly with ex vivo histomorphometry. Using volumetric IVUS end points, small sample sizes should be necessary to demonstrate effectiveness of strategies to reduce in-stent restenosis.


Subject(s)
Angioplasty, Balloon, Coronary/instrumentation , Fibromuscular Dysplasia/diagnostic imaging , Stents , Ultrasonography, Interventional , Animals , Coronary Vessels/diagnostic imaging , Sensitivity and Specificity , Swine , Tunica Media/diagnostic imaging
5.
Cathet Cardiovasc Diagn ; Suppl 3: 50-4, 1996.
Article in English | MEDLINE | ID: mdl-8874928

ABSTRACT

Rotational atherectomy is an effective transcatheter therapy for calcified coronary lesions. In large (> 3-mm) calcified coronary arteries, stent implantation following rotational atherectomy may further improve acute and especially, long-term benefit. To determine the safety and efficacy of this device synergy approach, we studied 24 consecutive patients undergoing this procedure electively in native coronary arteries. Procedural success was achieved in 100% without any major ischemic complications. There was also no incidence of subacute thrombosis or cardiac event during 30-day follow-up period. Thus, we conclude that elective stent implantation following rotational atherectomy in large, calcified coronary arteries is safe and results in excellent clinical benefit up to 30 days.


Subject(s)
Atherectomy, Coronary , Calcinosis/therapy , Coronary Disease/therapy , Stents , Aged , Calcinosis/diagnosis , Cohort Studies , Combined Modality Therapy , Coronary Angiography , Coronary Disease/diagnosis , Female , Follow-Up Studies , Humans , Male , Time Factors , Treatment Outcome , Ultrasonography, Interventional
6.
J Invasive Cardiol ; 8 Suppl B: 34B-42B, 1996.
Article in English | MEDLINE | ID: mdl-10785768
SELECTION OF CITATIONS
SEARCH DETAIL
...