[Determination of the effectiveness of antiblastic chemotherapy by morphologic signs of tumor cell damage]. / Opredelenie éffektivnosti antiblasticheskoi khimioterapii po morfologicheskim priznakam povrezhdeniia opukholevykh kletok

All known morphological signs of cell dystrophy are systematized. Each cell was described according to multiple morphological signs (100 cells in each specimen); 20 000 tumor cells in carcinomatous exudates of patients with different localizations of malignant tumor were studied during the course of treatment, and 9 100 cells of experimental Brown-Pearce tumors were subjected to various effects. There were revealed more informative signs for judging the efficacy of treatment in patients. Based on more informative signs, which proved to be nucleoli signs, the indices for nucleoli were elaborated to determine the degree of tumor cells injury and to estimate the efficacy of treatment of patients by means of alkylating antiblastic substances. A semiautomatic set "Cytoclassificator" was employed for the study.