ABSTRACT
We investigated whether the effect of neonatal hypoxia on amphetamine-induced hyperlocomotion can reproduce the ontogenic (age of onset) properties of schizophrenia. Neonatal hypoxia enhanced amphetamine-induced hyperlocomotion in adult mice and decreased it in adolescent mice. These findings provide ontogenic validity for this very simple animal model of schizophrenia.
Subject(s)
Dextroamphetamine/pharmacology , Hyperkinesis/chemically induced , Hypoxia/psychology , Schizophrenia/chemically induced , Age Factors , Animals , Animals, Newborn , Disease Models, Animal , Male , MiceABSTRACT
Sleep disorders have an increased incidence after menopause. The objective of this work was to evaluate the effects of isoflavone on some oxidative stress markers in postmenopausal women complaining of insomnia. Women aged between 50-65 years (n=38) were recruited and assigned to a double-blind placebo controlled study for 4 months. The treated group received 100 mg/day of isoflavones. Blood collections were conducted on three different occasions to assess total glutathione; superoxide dismutase and catalase in erythrocytes; lipid peroxidation; and homocysteine plasma concentrations. No differences between the groups were observed. However, all the patients seem to improve their oxidative stress status and homocysteine concentration after treatment. Superoxide dismutase activity was correlated with age and time of menopause at the beginning of the treatment, but these correlations were no longer observed by the end of the study. Soy isoflavones were not able to overcome the placebo effect for either oxidative stress parameters or homocysteine concentrations.
Subject(s)
Homocysteine/blood , Isoflavones/administration & dosage , Oxidative Stress/drug effects , Postmenopause/blood , Sleep Initiation and Maintenance Disorders/blood , Soybean Proteins/administration & dosage , Aged , Biomarkers/blood , Catalase/blood , Double-Blind Method , Erythrocytes/chemistry , Female , Glutathione/blood , Humans , Isoflavones/pharmacology , Lipid Peroxidation/drug effects , Middle Aged , Postmenopause/drug effects , Soybean Proteins/pharmacology , Superoxide Dismutase/blood , Time FactorsABSTRACT
Sleep disorders have an increased incidence after menopause. The objective of this work was to evaluate the effects of isoflavone on some oxidative stress markers in postmenopausal women complaining of insomnia. Women aged between 50-65 years (n=38) were recruited and assigned to a double-blind placebo controlled study for 4 months. The treated group received 100 mg/day of isoflavones. Blood collections were conducted on three different occasions to assess total glutathione; superoxide dismutase and catalase in erythrocytes; lipid peroxidation; and homocysteine plasma concentrations. No differences between the groups were observed. However, all the patients seem to improve their oxidative stress status and homocysteine concentration after treatment. Superoxide dismutase activity was correlated with age and time of menopause at the beginning of the treatment, but these correlations were no longer observed by the end of the study. Soy isoflavones were not able to overcome the placebo effect for either oxidative stress parameters or homocysteine concentrations.
