ABSTRACT
Malignant rhabdoid tumors are morphologically characterized by the presence of sheets of large polygonal cells with abundant cytoplasm containing eosinophilic inclusions. They have vesicular nuclei, often with prominent central nucleoli. The term rhabdoid tumor was originally coined to describe a group of rare, aggressive renal neoplasms of childhood. Since then, similar lesions, so-called extrarenal malignant rhabdoid tumors have been increasingly reported. The evidence to date suggests that, at least in extrarenal locations, rhabdoid tumors do not constitute a homogeneous entity, but rather represent the shared morphological pattern of a diverse range of malignant neoplasms. Although such rhabdoid features are not uncommon in metastatic malignant melanoma, they have only once been briefly described in a primary lesion. We report three further cases of cutaneous primary malignant melanoma with rhabdoid morphology.
Subject(s)
Melanoma/pathology , Rhabdoid Tumor/pathology , Skin Neoplasms/pathology , Adult , Biomarkers, Tumor/analysis , Female , Humans , Immunohistochemistry , Male , Melanoma/chemistry , Middle Aged , Rhabdoid Tumor/chemistry , Skin Neoplasms/chemistry , Vimentin/analysisABSTRACT
Sertoliform endometrioid adenocarcinomas of the ovary are well recognized but, curiously, a sertoliform pattern has not previously been noted in endometrioid adenocarcinomas of the endometrium. An endometrial tumour is described which showed in some areas the typical appearances of an endometrioid adenocarcinoma and in others a pattern closely resembling that of a Sertoli cell tumour.
Subject(s)
Adenocarcinoma/pathology , Endometriosis/pathology , Sertoli Cell Tumor/pathology , Uterine Neoplasms/pathology , Adenocarcinoma/diagnosis , Adult , Female , Humans , Uterine Neoplasms/diagnosisABSTRACT
Three children aged 18 months, 2 years and 3 years were involved in a house fire. Sadly, they all died. They did so at varying times after the incident, from almost immediately to 24 days. They all suffered a smoke inhalation injury. The histological findings from the large airways are presented and compared with reference to the stages in the healing process that they represent. Possible implications are discussed.
Subject(s)
Burns, Inhalation/pathology , Trachea/pathology , Wound Healing , Burns, Inhalation/physiopathology , Child, Preschool , Humans , Infant , Male , Mucous Membrane/pathology , Time Factors , Trachea/injuriesABSTRACT
Human coronary arteries were perfusion-fixed; sectioned and their external and lumenal circumferences measured by microscopic planimetry. They were found to dilate with increasing age, and this change seems to be more a degenerative process than a response to increasing heart weight. It is inferred that a moderate degree of coronary dilatation compensates for the tendency of atherosclerosis to occlude the lumen. Absence of any coronary dilatation might be hazardous in that the stenosing effects of atherosclerosis would be enhanced. By contrast over-dilatation (ectasia) is dangerous in that it causes a reduced flow-rate and, hence, promotes thrombosis.
Subject(s)
Coronary Disease/pathology , Coronary Vessels/pathology , Dilatation, Pathologic/pathology , Adult , Age Factors , Aged , Atrophy/pathology , Dilatation, Pathologic/etiology , Female , Humans , Male , Middle Aged , Sex FactorsABSTRACT
A case of multiple hepatic tumours in a patient treated for four years with high doses of oral contraceptives is described. Solitary hepatocellular lesions associated with conventional doses of oral contraceptives have been reported previously in twenty nine cases. Haemorrhage has been a common mode of presentation and is attributed to the marked vascularity of the lesions, an appearance referred to as peliosis hepatis. Radiographic studies show this term to be inappropriate as the vessels are of arterial origin. Another finding not previously reported is the presence of diffuse hyperplasia in the non-tumourous parts of the liver.
Subject(s)
Carcinoma, Hepatocellular/chemically induced , Contraceptives, Oral/adverse effects , Liver Neoplasms/chemically induced , Adult , Carcinoma, Hepatocellular/blood supply , Contraceptives, Oral/therapeutic use , Female , Hematoma , Humans , Liver Neoplasms/blood supply , Uterine Hemorrhage/drug therapyABSTRACT
A case of metastatic spread to the pleura from a glioma which had not been biopsied or treated surgically is reported. There was no direct extension to extracranial soft tissues, the route of spread apparently being by way of meningeal veins.
Subject(s)
Brain Neoplasms/pathology , Glioma/pathology , Pleural Neoplasms/pathology , Humans , Male , Neoplasm MetastasisSubject(s)
Chemotherapy, Cancer, Regional Perfusion/adverse effects , Leg , Lymph Node Excision/adverse effects , Melanoma/therapy , Amputation, Surgical , Female , Humans , Leg/surgery , Lymphatic Metastasis , Male , Melanoma/mortality , Melphalan/administration & dosage , Melphalan/therapeutic use , Neoplasm Recurrence, Local/surgery , Postoperative Complications/etiology , PrognosisSubject(s)
Infarction/diagnostic imaging , Kidney Cortex/diagnostic imaging , Kidney/blood supply , Acute Kidney Injury/etiology , Aged , Aortic Aneurysm/surgery , Collateral Circulation , Humans , Infarction/etiology , Infarction/pathology , Kidney/pathology , Kidney Cortex Necrosis/diagnostic imaging , Male , Postoperative Complications , UrographyABSTRACT
In a review of 574 cases of gastric carcinoma, 50 (8.7%) proved to be mucoid using defined microscopic criteria. Three histological types were recognized: pure signet-ring cell carcinoma (three cases); tumour of mixed pattern (41 cases); and an easily recognized, well differentiated type (six cases). This last group pursued an indolent course and had a mean survival time of nine years compared with mean survival times in the other two groups of five and 18 months respectively.
