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1.
Determination of tauromustine and its demethylated metabolites in plasma and urine.
Polacek, J; Gustafsson, B; Brandin, S; Ottersgård-Brorsson, A.
J Chromatogr ; 526(1): 151-7, 1990 Mar 16.
Article in English | MEDLINE | ID: mdl-2341526

ABSTRACT

A sensitive, selective and precise high-performance liquid chromatographic method for simultaneous determination of tauromustine and its demethylated metabolites in plasma and urine has been developed. It is based on solid-phase extraction on C18 sorbent and separation on a semipolar column. The analytical procedure is described in detail. The method has been validated with respect to linearity, recovery, selectivity, precision and detection limit. The stability of the determined substances in various media has also been studied.


Subject(s)
Antineoplastic Agents/blood , Chromatography, High Pressure Liquid/methods , Nitrosourea Compounds/blood , Taurine/analogs & derivatives , Antineoplastic Agents/pharmacokinetics , Antineoplastic Agents/urine , Humans , Nitrosourea Compounds/pharmacokinetics , Nitrosourea Compounds/urine , Taurine/blood , Taurine/pharmacokinetics , Taurine/urine
2.
Determination of tauromustine, a nitrosourea-based antitumour agent, in plasma by high-performance liquid chromatography.
Polacek, J; Gunnarsson, P O; Brandin, S.
J Chromatogr ; 425(2): 424-8, 1988 Mar 18.
Article in English | MEDLINE | ID: mdl-3372655

Subject(s)
Antineoplastic Agents/blood , Nitrosourea Compounds/blood , Taurine/analogs & derivatives , Administration, Oral , Animals , Antineoplastic Agents/pharmacokinetics , Chromatography, High Pressure Liquid , Dogs , Humans , Hydrogen-Ion Concentration , Nitrosourea Compounds/pharmacokinetics , Taurine/blood , Taurine/pharmacokinetics
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