ABSTRACT
This article describes the process of building an ontology to assist medical students and professionals specialized in Oncology. The ontology allows the user to obtain knowledge more quickly and thus assist professionals in their decision-making.
Subject(s)
Biological Ontologies , Breast Neoplasms/classification , Data Mining/methods , Internet/organization & administration , Medical Oncology/organization & administration , Natural Language Processing , Female , HumansABSTRACT
An infusion of Campomanesia xanthocarpa Berg. (Myrtaceae) leaves (Guabiroba) and the herb Cuphea carthagenensis (Jacq.) J.F. Macbr. (Lythraceae) (Sete-sangrias) is traditionally used in the South of Brazil to treat high levels of cholesterol and triglycerides. The effects of the aqueous extracts of these herbs were investigated in rats fed on a high calorie diet. Chronic treatment with the Guabiroba aqueous extract induced a significant reduction in weight gain in the rats, compared to the control group. Also, biochemical analysis showed that this treatment reduced the glycemia, while no effects on lipidic levels were observed. The biochemical analysis of the animals treated with Sete-sangrias aqueous extract showed no effect on glucose and triglyceride levels, while chronic treatment with the Sete-sangrias aqueous extract induced a significant reduction in plasma cholesterol in rats.
Subject(s)
Cuphea , Hypolipidemic Agents/pharmacology , Myrtaceae , Phytotherapy , Plant Extracts/pharmacology , Animals , Blood Glucose/drug effects , Cholesterol/blood , Hypolipidemic Agents/administration & dosage , Hypolipidemic Agents/therapeutic use , Male , Obesity/prevention & control , Plant Extracts/administration & dosage , Plant Extracts/therapeutic use , Plant Leaves , Rats , Rats, Wistar , Triglycerides/blood , Weight LossABSTRACT
HBV and HDV infections are a major health problem in the Amazon. This study evaluates the prevalence of these viruses within Indians groups, measuring the frequency of serological markers. The prevalence of past infection was 54.5% and HBsAg was found in 9.7%. An important variation of those markers was detected between villages, inclusively within the same ethnic group. None showed evidence of an acute infection. All HBeAg reactive were Apurinã, living in the same village and three of them from the same family. The prevalence of anti-HDT was 13.4% in HBsAg positive individuals. The authors observed high prevalence of HBV and HDV infection with the following pattern: low degree of infectivity, marked transmission in early ages, intra-familial dissemination, and lack of importance of vertical transmission. However, the results suggest that these viruses were not yet introduced effectively in some of the studied groups.
Subject(s)
Hepatitis B/epidemiology , Hepatitis D/epidemiology , Indians, South American , Adolescent , Adult , Aged , Aged, 80 and over , Brazil/epidemiology , Child , Child, Preschool , Female , Humans , Infant , Male , Middle AgedABSTRACT
This paper proposes a hybrid expert system (HES) to minimise some complexity problems pervasive to the artificial intelligence such as: the knowledge elicitation process, known as the bottleneck of expert systems; the model choice for knowledge representation to code human reasoning; the number of neurons in the hidden layer and the topology used in the connectionist approach; the difficulty to obtain the explanation on how the network arrived to a conclusion. Two algorithms applied to developing of HES are also suggested. One of them is used to train the fuzzy neural network and the other to obtain explanations on how the fuzzy neural network attained a conclusion. To overcome these difficulties the cognitive computing was integrated to the developed system. A case study is presented (e.g. epileptic crisis) with the problem definition and simulations. Results are also discussed.
Subject(s)
Artificial Intelligence , Decision Support Techniques , Algorithms , Fuzzy Logic , HumansABSTRACT
HBV and HDV infections are a major health problem in the Amazon. This study evaluates the prevalence of these viruses within Indians groups, measuring the frequency of serological markers. The prevalence of past infection was 54.5% and HBsAg was found in 9.7%. An important variation of those markers was detected between villages, inclusively within the same ethnic group. None showed evidence of an acute infection. All HBeAg reactive were Apurinã, living in the same village and three of them from the same family. The prevalence of anti-HDT was 13.4% in HBsAg positive individuals. The authors observed high prevalence of HBV and HDV infection with the following pattern: low degree of infectivity, marked transmission in early ages, intra-familial dissemination, and lack of importance of vertical transmission. However, the results suggest that these viruses were not yet introduced effectively in some of the studied groups.
A infecção pelo VHB e VHD são importantes problemas de saúde na Amazônia. Este estudo avalia a prevalência da infecção por esses agentes em sete grupos indígenas do Estado do Amazonas. A taxa de infecção passada pelo VHB encontrada foi de 54,5% e a de portadores do AgHBs de 9,7%. Observa-se variação importante destes marcadores entre as aldeias, inclusive da mesma etnia. Não evidenciamos marcador de infecção aguda, os quatro AgHBe reativos eram todos Apurinã, da mesma aldeia, e três da mesma família. O VHD foi encontrado em 13,4% dos AgHBs reativos. O padrão de infecção pelo VHB e VHD encontrado possui as seguintes características: endemicidade elevada, baixo potencial de infectividade, transmissão marcada em idade precoce, provável transmissão familiar, e pouca importância da transmissão vertical. Entretanto, também sugere que esses vírus não tenham sido ainda introduzidos efetivamente em algumas das etnias estudadas
Subject(s)
Female , Humans , Infant , Male , Middle Aged , Adolescent , Adult , Aged, 80 and over , Child , Child, Preschool , Hepatitis B/epidemiology , Hepatitis D/epidemiology , Indians, South American , Brazil/epidemiologyABSTRACT
This work presents a hybrid expert system (HES) intended to minimise some complex problems pervasive to knowledge engineering such as: the knowledge elicitation process, known as the bottleneck of expert systems; the choice of a model for knowledge representation to codify human reasoning; the number of neurons in the hidden layer and the topology used in the connectionist approach; the difficulty to extract an explanation from the network. Two algorithms applied to developing of HES are also suggested. One of them is used to train the fuzzy neural network and the other to obtain explanations on how the fuzzy neural network attained a conclusion. A case study is presented (e.g. epileptic crisis) with the inclusion of problem definition and simulations. The results are also discussed.
