Subject(s)
Lipoproteins, HDL , Phosphatidylcholines , Adult , Egg Yolk , Female , Humans , Lipoproteins, HDL/blood , Protein BindingSubject(s)
Adenine/analogs & derivatives , Adrenal Glands/metabolism , Aminoglutethimide/pharmacology , Cholesterol Esters/metabolism , Corticosterone/biosynthesis , Adenine/pharmacology , Adrenal Glands/drug effects , Adrenalectomy , Adrenocorticotropic Hormone/pharmacology , Animals , Cholesterol/metabolism , Female , Oleic Acids/metabolism , RatsSubject(s)
Arteries/metabolism , Arteriosclerosis/metabolism , Cholesterol/analogs & derivatives , Acyltransferases/antagonists & inhibitors , Acyltransferases/metabolism , Animals , Anticholesteremic Agents/pharmacology , Aorta/enzymology , Aorta/metabolism , Carbon Radioisotopes , Cholesterol/biosynthesis , Cholesterol, Dietary , Clofibrate/pharmacology , Coenzyme A Ligases/antagonists & inhibitors , Coenzyme A Ligases/metabolism , Esters/biosynthesis , Hydrogen-Ion Concentration , Macaca , Microsomes/enzymology , Microsomes/metabolism , Nafenopin/pharmacology , Oleic Acids/metabolism , RabbitsSubject(s)
Cholesterol/metabolism , Diabetes Mellitus/metabolism , Adipose Tissue/metabolism , Animals , Aorta/metabolism , Brain/metabolism , Cholesterol/blood , Cricetinae , Diabetes Mellitus/genetics , Disease Models, Animal , Hypercholesterolemia/metabolism , Intestinal Mucosa/metabolism , Liver/metabolism , Lung/metabolism , Muscles/metabolism , Skin/metabolism , Triglycerides/blood , TritiumSubject(s)
Aorta/metabolism , Diabetes Mellitus/metabolism , Glucose/metabolism , Animals , Blood Glucose/analysis , Carbon Dioxide/metabolism , Carbon Radioisotopes , Cricetinae , Diabetes Mellitus/genetics , Diabetic Ketoacidosis/metabolism , Disease Models, Animal , In Vitro Techniques , Insulin/administration & dosage , Insulin/blood , Insulin/pharmacology , Lactates/metabolism , Metabolism/drug effects , Pyruvates/metabolismSubject(s)
Adrenal Glands/metabolism , Angiotensin II/metabolism , Receptors, Cell Surface , Adrenocorticotropic Hormone/metabolism , Angiotensin II/analogs & derivatives , Animals , Binding, Competitive , Centrifugation, Density Gradient , Chromatography, Gel , Female , In Vitro Techniques , Peptide Hydrolases , Protein Binding , Rats , Temperature , Tritium , UltracentrifugationSubject(s)
Estradiol/metabolism , Receptors, Cell Surface , Uterus/metabolism , Animals , Binding Sites , Cattle , Cell Fractionation , Cell Nucleus/metabolism , Centrifugation, Density Gradient , Cytosol/metabolism , Endometrium/metabolism , Female , Kidney/metabolism , Liver/metabolism , Nafoxidine/pharmacology , RNA/biosynthesis , Rats , Stimulation, Chemical , TemperatureSubject(s)
Estrogens/metabolism , RNA/biosynthesis , Receptors, Cell Surface , Uterus/metabolism , Animals , Cattle , Cell Nucleus/metabolism , Cytosol/metabolism , DNA-Directed RNA Polymerases/metabolism , Endometrium/metabolism , Estradiol/metabolism , Female , In Vitro Techniques , Rats , TemperatureSubject(s)
Cell Nucleus/metabolism , Estradiol/metabolism , RNA/biosynthesis , Receptors, Cell Surface/drug effects , Uterus/metabolism , Animals , Binding Sites , Calcium/pharmacology , Cattle , Cell Nucleus/drug effects , Centrifugation, Density Gradient , Cytosol/drug effects , Cytosol/metabolism , Edetic Acid/pharmacology , Female , Hydrogen-Ion Concentration , Kinetics , Macromolecular Substances , Magnesium/pharmacology , Manganese/pharmacology , Models, Biological , Protein Binding , Temperature , Tritium , Uterus/cytology , Uterus/drug effectsSubject(s)
Estrogens/metabolism , Receptors, Drug , Animals , Cell Nucleus/metabolism , Centrifugation, Density Gradient , Cycloheximide/pharmacology , Cytoplasm/metabolism , Deoxyribonucleases , Diaphragm/metabolism , Estradiol/metabolism , Estrone/metabolism , Female , Hormones/metabolism , Protein Binding , Rats , Ribonucleases , Temperature , Tritium , Uterus/metabolismSubject(s)
Cell Nucleus/metabolism , Estradiol/metabolism , Receptors, Drug , Uterus/metabolism , Animals , Diethylstilbestrol/pharmacology , Estradiol/pharmacology , Estriol/pharmacology , Female , In Vitro Techniques , Rats , Testosterone/pharmacology , Tritium , Uterus/cytology , Uterus/drug effectsABSTRACT
The metabolism of labeled sex hormones was examined in human, canine, and rat aortas. Isolated arterial tissue converted estrone to estradiol, estradiol to estrone, and estrone sulfate to estrone and estradiol. The arterial wall also appeared to metabolize testosterone to androstenedione and an unidentified, relatively nonpolar derivative. Both estrogens and testosterone appeared to enter the arterial wall rapidly. No competition in arterial uptake between the two hormones was apparent. No specific arterial binding of estradiol could be demonstrated. The concentration of estradiol-(3)H in the canine aorta exceeded that in the plasma 1-6 hr after estradiol-(3)H administration. The uptake and disappearance of estradiol-(3)H in the aorta generally resembled the patterns observed in body tissues other than the adrenal gland and uterus. The uptake of estradiol-(3)H was greatest in the adrenal gland while its retention was maximum in the uterus.