ABSTRACT
The number and weight of cells in the cortical and subcortical structures of the cerebral and cerebellar motor system in albino rats after a long-term exposure to toluene. Toluene intoxication proved to kill projection neurons and interneurons in the sensorimotor cortex, ventrolateral thalamic nucleus, caudate nucleus, pallidum, red nucleus, and inferior olivary complex. The decreased number of cerebellar cells was mediated by atrophic changes as indicated by the decrease in the area and dry weight of Purkinje cells. The addition of plaferon LB to the diet attenuated the cytotoxic effect of toluene.
Subject(s)
Caudate Nucleus/metabolism , Cerebellar Nuclei/metabolism , Purkinje Cells/metabolism , Red Nucleus/metabolism , Solvents/toxicity , Toluene/toxicity , Ventral Thalamic Nuclei/metabolism , Animals , Caudate Nucleus/pathology , Cerebellar Nuclei/pathology , Neurons/metabolism , Neurons/pathology , Neuropeptides/pharmacology , Purkinje Cells/pathology , Rats , Red Nucleus/pathology , Ventral Thalamic Nuclei/pathologyABSTRACT
Different types of changes in glial cell reactions in organic and monolayer cultures are described. These changes are shown to reflect the behaviour of glial cells in vivo. A special attention is paid to the role of glial cells in the axon growth, and to their contractile activity and alterations under cytotoxic edema conditions. The establishment of intercellular contacts is shown to provide the general reaction of a group of glial cells.
Subject(s)
Brain/ultrastructure , Neuroglia/ultrastructure , Animals , Animals, Newborn , Astrocytes/ultrastructure , Axons/ultrastructure , Cells, Cultured , Chick Embryo , Culture Techniques , Cytological Techniques , Intercellular Junctions/ultrastructure , Microscopy, Electron , Rats , Time FactorsABSTRACT
In the conditions of cultivation of the transparent septum cells of newborn rat all cell types, inherent in this structure in vivo, are preserved and differentiate. The bioelectric activity is expressed in generating continuous pulse activity from the 9th day of cultivation on, thus suggesting the organotypic culture maturation.
Subject(s)
Septum Pellucidum/growth & development , Action Potentials , Animals , Animals, Newborn , Astrocytes/cytology , Astrocytes/physiology , Axons/cytology , Axons/physiology , Cell Differentiation , Culture Techniques , Electric Stimulation , Rats , Septum Pellucidum/cytology , Septum Pellucidum/physiologyABSTRACT
In order to study structural changes in the cerebellum the eye balls were enucleated in 6 adult cats. After unilateral and bilateral ablation of the eyes additional nerve fibres were found connecting the retina with the cerebellum. The retino-cerebellar accessary fibres come to the cerebellum mainly via the medial pedicle, solitary degenerated fibres were found in the medial and inferior pedicles of the cerebellum. Retino-cerebellar fibres were detected in the corklike, roof and dentate nuclei of the cerebellum. Retino-cerebellar straight fibres are projected into the white substance around the vermis as well as into the hemispheres of the cerebellum. No reticular-cerebellar fibres were found in the nucleus globosus.
