ECHOCARDIOGRAPHIC CHARACTERISTICS OF DIFFERENT WHO/ISH CARDIOVASCULAR DISEASE RISK GROUPS.

The objective of the study was to analyze association of echocardiographic TOD variables with the CVD risk groups defined by WHO/ISH. A cross-sectional study was conducted between (September 2008 - December 2010) Consecutive sample of 146 participants were enrolled in the study, 97 (66.4 %) women and (49) 33,6 % men, mean age. Study population was categorized in three groups according to WHO/ISH risk categories: Group 1 included population with risk less than 10% according to WHO/ISH, in Group 2 there were united two WHO/ISH risk categories (10-10.9% and 20-29.9%) and Group 3 represented population of 30-39.9% and more than 40% of CVD risk. Routine Echocardiography was conducted. The data was analyzed using SPSS, version 21. The distribution of echocardiography characteristics in WHO/ISH groups was statistically different for LA, PSP and EF (P<0.05). In groups I and II LA were only mildly dilated, while in group III was revealed moderate LA enlargement. The mean PSP was in normal range in groups I and II and mildly to moderate elevated in group III. The mean EF was in normal range for all the groups with tendency of reduction from group I to group III. Unlike this we have not found statistically significant differences in other echocardiographic variables, as IVS, PWT, LVD and LVEDV and they were in normal range for all risk groups. According to the findings of our study and considering that our study population is without any clinical presentation of cardiovascular disease and still have statistically significant tendency toward increase in LA and PSP we argue that those variables can be considered as early predictors of cardiovascular disease. Furthermore, it is recommended to include echocardiographic examination as part of the CVD risk evaluation protocol in selected population.

[EPIDEMIOLOGY, STRUCTURE AND ALGORITHM OF MANAGEMENT OF PREGNANT WOMEN WITH EXTRAGENITAL PATHOLOGY OF THERAPEUTIC PROFILE].

Purpose of the study - the study of the extragenital pathology (EGP) structure in pregnant women according to the requests for medical help. The screening survey was attended by 742 pregnant women. Average age was 28,4±5,5 years. A retrospective analysis of the causes of calls to pregnant ambulance carriages was carried out for 2012-2013. On the basis of obtained data was suggested an algorithm of pregnant women with EGP management. In the structure of EGP in one profile led hematology - 306 cases (41.2%), followed by nephrology - 290 (39.1%) and gastroenterology (38.8%) - 288 cases, respectively. In the structure of requests for emergency medical care for pregnant first place occupied by respiratory diseases (2012 r - 28%, 2013- 30%), followed by urinary system diseases (2012 - 19.6% 2013 - 17.2% r ). Obtained data formed the basis for the algorithm to identify risks and provide medical care for pregnant women with extragenital pathology. In the structure of the screening study prevailed hematology profile diseases, and respiratory system diseases often were the reason for emergency medical care. The result of this study became the creating of the algorithm for medical care delivery.

ASSOCIATION OF ECHOCARDIOGRAPHIC CHARACTERISTICS WITH CARDIOVASCULAR RISK FACTORS IN ADULTS WITHOUT CLINICAL MANIFESTATION OF HEART FAILURE.

The objective the study was to assess the association between echocardiographic parameters and established cardiovascular risk factors in adults without clinical manifestation of heart failure (HF). A cross-sectional study was conducted between (September 2008 - December 2010) Consecutive sample of 177 participants were enrolled in the study. We performed routine Transthoracic Echocardiography and evaluated several well established cardiovascular risk factors. The data was analyzed using SPSS, version 16. LA was significantly correlated with age (r 0.396, p<0.000), WC (r 0.291, p<0.005), BMI (r 0.233, p<0.005), SBP (r 0.208, p<0.012) and TCH (r 0.163, p<0.049); IVS - with age (r 0.318, p<0.000), WC (r 0.259, p<0.002), BMI (r 0.178, p<0.032), TCH (r 0.191, p<0.022); PWT - with age (r 0 313, p<0.000), WC (r 0.270, p<0.001), BMI (r 0.204, p<0.013), TCH (r 0.168, p<0.042); LVD - WC (r 0.201, p<0.015) and BG (r 0.176, p<0.034); with LVEDV - WC (r 0.240, p<0.004); with EF - SBP (r- 0.202, p<0.015), DBP (r -0.171, p<0.015) and with PSP - age (r 0.286, p<0.000), SBP (r-0.243, p<0.003), DBP (r 0.254, p<0.002). As echocardiography characteristics are independent risk factors for Heart Failure development and progression and as most of them are correlated the age and obesity variables it should be appropriate to conduct routine echocardiography in aged and obese patients even in low CVD risk group. This statement particularly relevant for Georgia as the frequency of obesity is very high in the Georgian population.