ABSTRACT
UNLABELLED: Negative pressure therapy (NPT), used on open wounds or postoperative infections, has not been evaluated on closed spinal incisions. This was analyzed after 3 days and 5 days of NPT application using biomechanics and histology in a porcine model. METHODS: In 8 mature miniature pigs, 2 end-to-end midline spine incisions were closed in a standard fashion. Negative pressure (Prevena™ Incision Management System, KCI, San Antonio,TX) was applied to one incision (NPT group) while standard dry dressings were used on the other (control group). After 3 days or 5 days, all incisions underwent biomechanical (eg, failure load, failure energy, and stress), histological, and scar scale evaluation. ANALYSIS: ANOVAs compared the groups (3-day vs 5-day, NPT vs control, P < 0.05). Negative pressure therapy demonstrated a significantly improved scar scale height grade than the control (P = 0.026). Failure load (4.9 ± 4.0 vs 16.5 ± 14.6 N), energy absorbed (8.0 ± 9.0 vs. 26.9 ± 23.0 mJ), and ultimate stress (62 ± 53 vs. 204 ± 118 N/mm2) were lower in the control group. Histological analysis revealed no differences in incision scar width. CONCLUSION: Negative pressure therapy application on closed incisions presented a trend toward improved early healing strength, and in significantly improved incision appearance. Clinically, NPT may improve incision integrity, minimizing the risk of dehiscence or subsequent infection. Patients at high risk of postoperative incision site complications may benefit from primary application of NPT.
ABSTRACT
A wandering or ectopic spleen, a rare congenital condition caused by improper fixation of the ligamentous attachments, was identified during a postmortem examination of a 10-month-old female who had died of Streptococcus pneumoniae sepsis. The wandering spleen was autoinfarcted and adherent to the left hepatic lobe, with resultant functional hyposplenism.
