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Clin Infect Dis ; 69(3): 542-545, 2019 07 18.
Article in English | MEDLINE | ID: mdl-30590481

ABSTRACT

In a pilot study, heavy water labeling was used to determine hepatitis B surface antigen (HBsAg) turnover rates in chronic hepatitis B (CHB) patients. The mean (standard deviation) half-life of HBsAg in blood was 6.7 (5.5) days, which reflects recent production in the liver and supports strategies aimed at reducing HBsAg production in CHB patients.


Subject(s)
Deuterium Oxide/administration & dosage , Hepatitis B Surface Antigens/blood , Hepatitis B, Chronic/blood , Hepatitis B, Chronic/virology , Administration, Oral , Adult , Aged , DNA, Viral/blood , Female , Half-Life , Hepatitis B e Antigens/blood , Humans , Liver/virology , Male , Middle Aged , Pilot Projects , Saliva/virology
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