ABSTRACT
A 79-year-old woman suffering from Parkinson's disease, for which she was taking a levodopa-carbidopa preparation, was prescribed the selective serotonin reuptake inhibitor paroxetine 20 mg once daily. After taking the first tablet she started to suffer from visual hallucinations. Once she stopped taking the paroxetine, the hallucinations ceased immediately. A link between the paroxetine and the hallucinations seemed likely, with a possible interaction between the paroxetine and the levodopa-carbidopa combination.
Subject(s)
Antiparkinson Agents/therapeutic use , Hallucinations/chemically induced , Parkinson Disease/drug therapy , Paroxetine/adverse effects , Selective Serotonin Reuptake Inhibitors/adverse effects , Aged , Antiparkinson Agents/administration & dosage , Carbidopa/administration & dosage , Carbidopa/therapeutic use , Drug Interactions , Drug Therapy, Combination , Female , Humans , Levodopa/administration & dosage , Levodopa/therapeutic use , Paroxetine/therapeutic use , Selective Serotonin Reuptake Inhibitors/therapeutic useABSTRACT
A double-blind randomized crossover study was performed in 56 chemotherapy-naive patients, all receiving non-cisplatin-based chemotherapy, to compare the antiemetic effects of 2 doses of a single administration of methylprednisolone succinate (Solu-Medrol): 250 versus 500 mg. Among the 39 patients who satisfactorily completed both parts of the study, complete and major protection from emesis (0 and 1 emetic episode or only retching) was observed in 79% during the first course and in 69% during the second course. Treatment failure (> or = 6 episodes of vomiting) was observed in 18% during the first course and 21% during the second course. There was no significant difference between the two dose levels neither in terms of antiemetic protection nor in terms of the occurrence of side effects nor in patient preference. Most important side effects were facial flushing (45%), headache (22%) and facial edema (18%). It is concluded that, although a comparison with lower dosages cannot be made, within the dose range studied no clear dose-response relationship could be found.