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1.
JAMA Otolaryngol Head Neck Surg ; 142(10): 972-979, 2016 10 01.
Article in English | MEDLINE | ID: mdl-27467967

ABSTRACT

Importance: The accuracy of the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) risk calculator has been assessed in multiple surgical subspecialties; however, there have been no publications doing the same in the head and neck surgery literature. Objective: To evaluate the accuracy of the calculator's predictions in a single institution's total laryngectomy (TL) population. Design, Setting, and Participants: Total laryngectomies performed between 2013 and 2014 at a tertiary referral academic center were evaluated using the risk calculator. Predicted 30-day outcomes were compared with observed outcomes for return to operating room, surgical site infection, postoperative pneumonia, length of stay, and venous thromboembolism. Main Outcomes and Measures: Comparison of the NSQIP risk calculator's predicted postoperative complication rates and length of stay to what occurred in this patient cohort using percent error, Brier scores, area under the receiver operating characteristic curve, and Pearson correlation analysis. Results: Of 49 patients undergoing TL, the mean (SD) age at operation was 59 (9.3) years, with 67% male. The risk calculator had limited efficacy predicting perioperative complications in this group of patients undergoing TL with or without free tissue reconstruction or preoperative chemoradiation or radiation therapy with a few exceptions. The calculator overestimated the occurrence of pneumonia by 165%, but underestimated surgical site infection by 7%, return to operating room by 24%, and length of stay by 13%. The calculator had good sensitivity and specificity of predicting surgical site infection for patients undergoing TL with free flap reconstruction (area under the curve, 0.83). For all other subgroups, however, the calculator had poor sensitivity and specificity for predicting complications. Conclusions and Relevance: The risk calculator has limited utility for predicting perioperative complications in patients undergoing TL. This is likely due to the complexity of the treatment of patients with head and neck cancer and factors not taken into account when calculating a patient's risk.


Subject(s)
Laryngectomy , Postoperative Complications , Female , Forecasting , Humans , Male , Middle Aged , Postoperative Complications/prevention & control , Quality Improvement , Risk Assessment/methods
2.
Head Neck ; 37(1): 117-24, 2015 Jan.
Article in English | MEDLINE | ID: mdl-25646551

ABSTRACT

BACKGROUND: The purpose of this study was to report outcomes of proton therapy in head and neck adenoid cystic carcinoma. METHODS: We conducted a retrospective analysis of 26 patients treated between 2004 and 2012. Twenty patients (77%) had base of skull involvement; 19 (73%) were treated for initial disease and 7 (27%) for recurrent disease. Twenty patients were treated postoperatively, 6 after biopsy alone and 24 had positive margins or gross residual disease.Median dose delivered was 72 Gy (relative biological effectiveness[RBE]). RESULTS: Median follow-up was 25 months (range, 7­50 months). The 2-year overall survival was 93% for initial disease course and 57% for recurrent disease (p5.19). The 2-year local control was 95% for initial disease and 86% for recurrent disease (p5.48). The 2-year distant metastatic rate was 25%. Late toxicity of grade 0 or 1 was seen in 17 patients, grade 2 in 5, grade 3 in 2, grade 4 in 1, and grade 5 in 1. CONCLUSION: Initial outcomes of proton therapy are encouraging. Longer follow-up is required.


Subject(s)
Carcinoma, Adenoid Cystic/radiotherapy , Head and Neck Neoplasms/radiotherapy , Proton Therapy , Adult , Aged , Carcinoma, Adenoid Cystic/mortality , Carcinoma, Adenoid Cystic/pathology , Disease-Free Survival , Female , Follow-Up Studies , Head and Neck Neoplasms/mortality , Head and Neck Neoplasms/pathology , Humans , Male , Middle Aged , Radiotherapy Dosage , Retrospective Studies , Survival Rate , Treatment Outcome , Young Adult
3.
JAMA Otolaryngol Head Neck Surg ; 139(12): 1306-11, 2013 Dec.
Article in English | MEDLINE | ID: mdl-24158536

ABSTRACT

IMPORTANCE: Head and neck basaloid squamous cell carcinoma (BSCC) has been considered a more aggressive variant of squamous cell carcinoma (SCC) with a poorer prognosis, although case-control studies have reached conflicting conclusions. OBJECTIVE: To examine the prognostic significance of head and neck BSCC on overall survival in a large population-based registry. DESIGN AND SETTING: Retrospective data review of a population-based registry from the Surveillance, Epidemiology, and End Results database. PARTICIPANTS: Individual case data for 34,196 patients treated between January 2004 and December 2009 with head and neck primary SCC (n = 33,554) and BSCC (n = 642) of the oral cavity, oropharyx, larynx, or hypopharynx. Patients with metastatic disease, incomplete staging information, and those who did not receive surgery or radiation were excluded. INTERVENTIONS: Patients had been treated with surgery, radiation, or both. MAIN OUTCOMES AND MEASURES: Distribution of patient characteristics between patients of each histology. Hazard ratios, 3-year overall survival, subgroup, and multivariate analysis of patient and treatment characteristics were investigated. RESULTS: Across each cohort, patients with BSCC more often had high-grade tumors and treatment with lymph node dissection. Multivariate analysis found that group stage, T stage, N stage, size, lymph node dissection, and age statistically significantly influenced overall survival. In multivariate analysis, the hazard ratio for death for patients with BSCC in the oral cavity and larynx and hypopharynx was not statistically significantly different from that for SCC. In the oropharynx, the hazard ratio for death for BSCC histology compared with SCC histology was 0.73 (P = .03). CONCLUSIONS AND RELEVANCE: Compared with SCC, BSCC is not an independent adverse prognostic factor for patients with head and neck cancer. The Surveillance, Epidemiology, and End Results analysis has limits, including lack of information regarding chemotherapy, but after controlling for disease and treatment variables, including neck dissection and radiotherapy, BSCC histology did not have an independent adverse prognostic effect on overall survival. The reported association between human papillomavirus and BSCC histology may explain the lower hazard ratio for death in patients with oropharynx BSCC.


Subject(s)
Carcinoma, Basosquamous/mortality , Carcinoma, Basosquamous/pathology , Carcinoma, Squamous Cell/mortality , Carcinoma, Squamous Cell/pathology , Head and Neck Neoplasms/mortality , Head and Neck Neoplasms/pathology , Aged , Aged, 80 and over , Biopsy, Needle , Carcinoma, Basosquamous/therapy , Carcinoma, Squamous Cell/therapy , Cause of Death , Combined Modality Therapy , Female , Head and Neck Neoplasms/therapy , Humans , Male , Middle Aged , Multivariate Analysis , Neck Dissection/methods , Neoplasm Invasiveness/pathology , Neoplasm Staging , Prognosis , Proportional Hazards Models , Radiotherapy, Adjuvant , Registries , Retrospective Studies , Risk Assessment , SEER Program , Survival Analysis , Treatment Outcome
4.
Otolaryngol Head Neck Surg ; 140(6): 912-6, 2009 Jun.
Article in English | MEDLINE | ID: mdl-19467414

ABSTRACT

OBJECTIVE: Review surgical management of obstructive sleep apnea (OSA) in infants and young toddlers compared with a medically treated group. STUDY DESIGN: Case series with chart review of children younger than 24 months treated at a tertiary pediatric hospital between 2000 and 2005. SUBJECTS AND METHODS: Surgical treatment included adenotonsillectomy, adenoidectomy, and tonsillectomy. Polysomnography results, comorbidities, and major complications were recorded. The change in apnea-hypopnea index (AHI) before and after treatment was analyzed. Logistic regression analysis reviewed effects of comorbidities and OSA severity on complications. RESULTS: A total of 73 children met inclusion criteria. The surgical treatment group (AHI) improved posttreatment: mean AHI change was 9.6 (95% CI, 5.8-13.4). The medical treatment group did not improve posttreatment: mean AHI change was -3.0 (95% CI, -15.1 to 9.1). The difference in AHI change between surgical and medical groups was 12.56 (95% CI, 2.7-22.4). An independent t test found this difference to be statistically significant (P = 0.01). Eleven (18%) patients suffered significant postoperative surgical complications; 55 surgical patients and 8 medical patients had comorbidities. There were no long-term morbidities or mortalities. CONCLUSIONS: AHI in the surgically treated group significantly improved. The complication rate for a tertiary pediatric hospital population that included patients with multiple comorbidities was acceptable.


Subject(s)
Sleep Apnea, Obstructive/surgery , Adenoidectomy , Child, Preschool , Comorbidity , Female , Humans , Infant , Logistic Models , Male , Polysomnography , Postoperative Complications , Tonsillectomy , Treatment Outcome
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