Subject(s)
Humans , Female , Adult , Venous Thrombosis/diagnosis , Fingers/blood supply , Hand/blood supply , DermoscopyABSTRACT
BACKGROUND: Whether melanoma in histological contiguity with a naevus [naevus-associated melanoma (NAM)] is distinctly different from melanoma arising de novo remains unclear. OBJECTIVES: To determine whether the characteristics of de novo melanoma differ from NAM and are not due to naevus obliteration in thicker tumours. METHODS: We conducted a multicentre retrospective study of de novo melanoma and NAM in seven referral centres in Europe, Australia and the USA between 2006 and 2015. RESULTS: In a total of 9474 localized melanomas, de novo melanoma was associated with thicker tumours and body site differences compared with NAM. In the subset of T1 melanomas (n = 5307), similar body site differences were found in multivariate analysis by body site. When compared with NAM, de novo melanoma was more likely to affect older individuals (≥ 70 years) when located on the head/neck [odds ratio (OR) 4·65, 95% confidence interval (CI) 2·55-8·46], the trunk (OR 1·82, 95% CI 1·40-2·36) or the upper extremity (OR 1·69, 95% CI 1·14-2·50), was more likely to affect female patients when located on the lower extremities (OR 1·36, 95% CI 1·03-1·80), and was more likely to be of the nodular melanoma subtype (OR 2·23, 95% CI 1·14-4·35) when located on the trunk. De novo melanoma was less likely to have regression present compared with NAM. CONCLUSIONS: Clinicopathological and body site differences between de novo melanoma and NAM support the divergent pathway model of development. These differences were also found in thin melanomas, suggesting that de novo melanomas are different from NAM and their differences are not due to the obliteration of naevus remnants in thicker tumours.
Subject(s)
Melanoma , Skin Neoplasms , Australia , Europe/epidemiology , Female , Humans , Melanoma/epidemiology , Retrospective Studies , Skin Neoplasms/epidemiologyABSTRACT
No disponible
Subject(s)
Humans , Female , Aged, 80 and over , Skin Neoplasms/surgery , Surgical Flaps , Plastic Surgery Procedures/methods , Umbilicus/surgery , Umbilicus/pathology , Groin/diagnostic imaging , Groin/pathology , Tomography, X-Ray Computed , Sentinel Lymph Node Biopsy/methods , Antibiotic ProphylaxisSubject(s)
Microcirculation , Models, Theoretical , Optical Imaging/methods , Skin/blood supply , Surgical Flaps/blood supply , Aged , Aged, 80 and over , Blood Pressure , Face , Female , Humans , Lasers , Pilot ProjectsSubject(s)
Asymptomatic Diseases , Head and Neck Neoplasms/pathology , Hemangiosarcoma/pathology , Scalp , Skin Neoplasms/pathology , Aged , Humans , MaleABSTRACT
Fibroblastic rheumatism is a rare fibro-proliferative disease, of unknown etiology. It is characterized by sudden onset of symmetric inflammatory polyarthritis simultaneously or preceded by multiple cutaneous nodules, ranging from 5 to 20mm in diameter, with predilection for the upper and lower extremities. With only a few dozens of cases described, it has a worldwide distribution, affecting primarily caucasians of all ages (cases described ranging 8 to 68 years), without gender predilection. The authors describe the case of a patient presenting multiple cutaneous nodules located on the back of the hands, without any articular or sistemyc complaints. Correlation between clinical and histopathological aspects led to the diagnosis and treatment, with a favorable outcome.
