ABSTRACT
A retrospective analysis of staging results from 308 patients with Hodgkin's disease (HD) was performed in order to relate clinico-pathological findings with respect to the liver to other staging results and to prognosis. Thirty-four patients had clinically enlarged liver, 80 had increased serum-enzyme levels indicating possible liver damage, but only 10 patients had biopsy-proven histologic evidence of HD in the liver (7 primary biopsies, 3 re-biopsies). Among the prognostic correlations not only advanced stage and liver infiltrates were connected to poor prognosis, but also--even in early stages--elevated serum enzyme values (S-GOT and alkaline phosphate).
Subject(s)
Hodgkin Disease/pathology , Liver/pathology , Adolescent , Adult , Aged , Alkaline Phosphatase/blood , Aspartate Aminotransferases/blood , Child , Child, Preschool , Female , Hodgkin Disease/mortality , Hodgkin Disease/physiopathology , Humans , Liver Function Tests , Male , Middle Aged , Neoplasm Staging , Prognosis , Retrospective StudiesABSTRACT
Histopathologic findings in 459 liver biopsies performed in 308 patients with Hodgkin's disease were reviewed. Typical Hodgkin infiltrates were found in only 11/459 biopsies (2.4%) and infiltrates suspect for Hodgkin's disease in only 8/459 (1.7%), whereas unspecific changes were more common. Lymphocytic infiltration was seen in 47% of the biopsies and focal necrosis in 19%. No correlation could be demonstrated between unspecific changes and clinical characteristics, including prognosis.
Subject(s)
Hodgkin Disease/pathology , Liver/pathology , Adolescent , Adult , Aged , Child , Child, Preschool , Female , Hodgkin Disease/mortality , Humans , Male , Middle Aged , Prognosis , Retrospective Studies , Spleen/pathologySubject(s)
Lymphoma/physiopathology , Thyroid Gland/physiopathology , Adult , Aged , Female , Hodgkin Disease/physiopathology , Humans , Lymphoma, Large B-Cell, Diffuse/physiopathology , Lymphoma, Non-Hodgkin/physiopathology , Male , Middle Aged , Thyroid Function Tests , Thyrotropin/blood , Thyroxine/blood , Triiodothyronine/bloodABSTRACT
Thyroid function was studied in 36 patients with various stages of malignant lymphoma. Stage IVB patients exhibited characteristic changes in thyroid biochemistry in the form of lowered triiodothyronine (T3) and elevated free thyroxine (FT4), but normal thyroxine. Moreover, the concentration of thyroxine-binding prealbumin and albumin was lowered, whereas thyroxine-binding globulin was normal. Thyroid-stimulating hormone was slightly elevated but showed a normal increase after administration of thyrotrophin-releasing hormone. Patients with less extensive disease differed only slightly from the controls. The results agree with previous studies of patients suffering from other chronic diseases. The mechanisms underlying the hormonal changes have been only partially elucidated. When investigating patients with disseminated malignant disease for thyroid disease, the above mentioned changes in thyroid biochemistry must be borne in mind. Single analyses of FT4 and T3 may give rise to a false assumption of hyper- or hypothyroid states in patients who are in fact euthyroid.
