ABSTRACT
We analyzed biocompatibility, elastic-strength properties, and biointegration potential of a new biomaterial made of xenopericardium for reconstructive cardiovascular surgery. The biomaterial manufactured by the proposed technology demonstrated high biocompatibility and biointegration potential and its elastic-strength properties 2-4-fold surpassed that of native pericardium. The obtained results attested to good prospects of using the proposed technology for preparing biomaterials for reconstructive cardiovascular surgery.
Subject(s)
Biocompatible Materials/chemistry , Cardiovascular Surgical Procedures/methods , Pericardium/surgery , Plastic Surgery Procedures/methods , Animals , Male , Rats , Rats, WistarSubject(s)
Calcinosis/physiopathology , Coronary Vessels/transplantation , Heart Valves/transplantation , Mitochondria, Heart/physiology , Calcinosis/metabolism , Calcium/metabolism , Humans , Microscopy, Electron , Mitochondria, Heart/metabolism , Mitochondria, Heart/ultrastructure , Muscle, Smooth, Vascular/cytology , Muscle, Smooth, Vascular/metabolism , Muscle, Smooth, Vascular/ultrastructure , Transplantation, HomologousABSTRACT
Inoculation of cells derived from the aorta of Wistar rats on devitalized porcine aortic walls 2-4-fold reduced their calcinosis after subcutaneous implantation to Wistar rats. Inoculation of Wistar rat bone marrow mesenchymal cells selected by adhesion activity did not reduce tissue calcinosis. The results indicate good prospects of repopulation of devitalized heart valve and vessel transplants by recipient vascular cells for reducing transplant calcinosis and improvement of their biocompatibility.
