ABSTRACT
INTRODUCTION: Reconstructing a crooked nose has been a challenge. Reshaping a nose reducing or improving its profile may be followed by irregularities and functional troubles. The principles of the extracorporeal septoplasty were launched in the 50's, consisting of the treatment of the septal framework outside the nose. Thus, it is replaced and fixed inside the nose. Dorsal irregularity or low projection may be overcome with a dorsal onlay graft. OBJECTIVE: To describe an evolution of extracorporeal rhinoseptoplasty based on a three-dimensional reshaping of the nasal framework, and its average dimensions. PATIENTS AND METHODS: Data of patients presenting nasal obstruction related to septal deviation and operated by the proposed technique were collected prospectively. The dimensions of the framework were measured during the surgery. RESULTS: 25 patients were operated from February to September 2010. Fifteen (60%) cases were related to previous trauma or surgery. The other 40% (N=10) were primary, claiming mainly a reduction rhinoplasty. A closed approach was used for all but one (4%). In 12% (N=3) of the patients no lateral osteotomies were performed after opening the bony roof. Tip surgery was performed in 32% (N=8). CONCLUSIONS: The principles of the "three-dimensional framework technique" are globally reproducible independently of the amount of residual septal cartilage. We believe that our technique assures more stability to the framework and offers a better regularity of the nasal dorsum, eliminating the need of an open approach if other manoeuvres requiring it are not associated.
Subject(s)
Nasal Septum/surgery , Rhinoplasty/methods , Adolescent , Adult , Female , Humans , Male , Middle Aged , Nasal Obstruction/etiology , Nasal Obstruction/surgery , Nasal Septum/abnormalities , Nasal Septum/injuries , Prospective Studies , Young AdultABSTRACT
Nitrofurazona(NF), 5-nitro-2-furaldeído semicarbazona, é um antibiótico de amplo espectro, que apresenta diversos efeitos tóxicos e baixa solubilidade aquosa. A complexação da NF com ciclodextrinas é de grande interesse para o desenvolvimento de uma formulação para este antibiótico que seja mais segura e eficiente. Neste trabalho foi realizada a preparação e caracterização inicial do complexo de inclusão entre NF e hidroxipropil-Beta-ciclodextrina (HP-Beta-CD) através de experimentos para determinação da cinética de complexação, medidas de fotoestabilidade, medidas de constante de afinidade fármaco: ciclodextrina, ensaios de liberação in vitro, estequiometria de formação do complexo e morfologia do complexo por microscopia eletrônica de varredura. Os ensaios de cinética de complexação mostram que para o complexo atingir o equilíbrio são necessárias 17,3h. As isotermas de solubilidade determinadas para a NF em função da temperatura mostraram perfis do tipo A e B indicando que a temperatura é um fator importante na complexação da NF com ciclodextrina. Os experimentos de fotoestabilidade indicam que a inserção da molécula de NF na cavidade interna da ciclodextrina protege o fármaco da fotodecomposição. A cinética de liberação mostra que o perfil de liberação do fármaco é modificado pela presença da ciclodextrina no meio. A estequiometria de complexação entre NF e HP-Beta-CD determinada foi de 1:1 NF:HP-Beta-CD. Os resultados demicroscopia eletrônica de varredura indicam alterações na estrutura cristalina da NF em presença deciclodextrina. Este estudo está baseado na caracterização físico-química da complexação entre NF e HP-Beta-CD podendo ser uma nova potencial opção para utilização terapêutica do NF.
Nitrofurazone (NF), 5-nitro-2-furaldehyde semicarbazone, a broad-spectrum antibiotic, has reported toxic effects and low solubility in water. It would be of great interest to form inclusion complexes between NF and a cyclodextrin, to develop more effective and safer antibiotic formulations. This paper focuses on the preparation of inclusion complexes of NF with 2- hydroxypropyl- -cyclodextrin (HP- -CD) and their initial characterization by evaluating rates of complex formation, photostability, solubility isotherms, release rate profiles, stoichiometry of the complexes and their morphology, as revealed by scanning electron microscopy. The kinetic tests of complex formation revealed that 17,3 h is enough for stabilization of the NFcyclodextrin complex. The solubility isotherm studies showed that the isotherm changes from type A to type B, as a function of temperature. The photostability experiments showed that the insertion of the NF in the HP- -CD cavity protects the drug from photodecomposition. The release kinetic tests showed that the profile of NF release from the complex is altered by the presence of HP- -CD in the medium. A Job's plot indicated that the stoichiometry of the complex was 1:1 NF:HP- -CD. The scanning electron micrographs showed changes in the crystal structure of NF in the complex. This study focused on the physicochemical properties of drug-delivery formulations that could potentially be developed into a novel type of therapy with NF.