Subject(s)
Alopecia , Leprosy , Alopecia/pathology , Cicatrix/pathology , Eyebrows/pathology , Humans , Leprosy/complications , Leprosy/pathologySubject(s)
Alopecia/diagnosis , Cicatrix/diagnosis , Cosmetics/adverse effects , Photosensitivity Disorders/diagnosis , Sunlight/adverse effects , Adult , Aged , Alopecia/etiology , Alopecia/pathology , Cicatrix/etiology , Cicatrix/pathology , Eyebrows , Female , Fibrosis , Humans , Male , Middle Aged , Patch Tests , Photosensitivity Disorders/etiology , Photosensitivity Disorders/pathology , Skin/drug effects , Skin/pathology , Skin/radiation effectsABSTRACT
Wall rocket (Diplotaxis erucoides) is a common Crucifera plant that grows in European and American vineyards and olive groves. We present the cases of 2 farmers with rhinoconjunctivitis and asthma related to wine-growing tasks during D erucoides pollination (March-April). The aim of this work was to demonstrate that occupational symptoms were caused by D erucoides pollen sensitization. Cutaneous tests, specific IgE measurements, conjunctival and bronchial provocation tests, and peak-flow measurements during working days were performed.
Subject(s)
Asthma/diagnosis , Conjunctivitis, Allergic/diagnosis , Occupational Diseases/diagnosis , Plants/immunology , Rhinitis, Allergic, Seasonal/diagnosis , Adult , Allergens/immunology , Allergens/ultrastructure , Bronchial Provocation Tests , Forced Expiratory Volume , Humans , Immunoglobulin E/biosynthesis , Male , Plants/anatomy & histology , Pollen/immunology , Pollen/ultrastructure , Skin TestsABSTRACT
In the scope of a research program aiming at the synthesis and pharmacological evaluation of novel possible antiplatelet prototype compounds, exploring bioisosterism principles for molecular design, we describe in this paper the synthesis of new aryl-sulfonamides derivatives, structurally similar to known thromboxane A2 receptor antagonists. The synthetic route used to access the new compounds described herein starts from safrole, an abundant Brazilian natural product, which occurs in Sassafras oil (Ocotea pretiosa). The results from preliminary evaluation of these novel aryl-sulfonamide compounds by the platelet aggregation inhibitory test, using rabbit PRP, induced by ADP, collagen, arachidonic acid, and U46619, identified the N-[2-(4-carboxymethoxyphenyl)ethyl]-6-methyl-3,4-methylenedioxyphe nyl- sulfonamido derivative as the most active among them, presenting in IC50 value for the U-46619-induced platelet aggregation in rabbit platelet-rich plasma: 329 microM.
