ABSTRACT
Olanzapine is an atypical antipsychotic drug that has been increasingly used in acute treatment of, and therapeutic support for, schizophrenia, bipolar disorder and other psychoses. Considering that olanzapine acts on the dopaminergic receptor and this receptor is detected in germ cells, the present study aims to investigate the effects of treatment with different doses of olanzapine on spermatogenesis, plasma testosterone and weight of androgen-dependent organs in rats. Results showed reduced plasma testosterone levels, and reduced testis, epididymis and prostate weights. Histopathologic and histomorphometric analysis of spermatogenesis indicated testicular degeneration. Furthermore, germ cell desquamation, syncytial multinucleated cells, Sertoli cell vacuolization and presence of necrotic and apoptotic germ cells wwew observed. Olanzapine treatment in rats promoted endocrinological changes and lesions in the testis, leading to a disturbance in spermatogenesis.
Subject(s)
Antipsychotic Agents/toxicity , Benzodiazepines/toxicity , Genital Diseases, Male/chemically induced , Spermatogenesis/drug effects , Testis/drug effects , Animals , Apoptosis/drug effects , Body Weight/drug effects , Cell Count , Epididymis/drug effects , Epididymis/pathology , Genital Diseases, Male/blood , Genital Diseases, Male/pathology , Lethargy/chemically induced , Male , Necrosis/chemically induced , Necrosis/pathology , Olanzapine , Organ Size/drug effects , Prostate/drug effects , Prostate/pathology , Rats , Rats, Wistar , Sertoli Cells/drug effects , Sertoli Cells/pathology , Spermatocytes/drug effects , Spermatocytes/pathology , Testis/pathology , Testosterone/bloodABSTRACT
Peripheral nerves are structures exposed to physical, chemical and mechanical traumas. These lesions can cause a varying magnitude of damages, between which compression, distention and section, which culminate in motor, psychological and aesthetic alterations, mainly with facial expression nerves, like the facial nerve. The objective of this study was to verify the fascicular disposition of the facial nerve through its histology. Ten human cadaver heads, with ages between 53 and 66, were dissected. Extratemporal segments of the facial nerve were collected and routine techniques for histological microscopic evaluation were applied. Results showed that the extratemporal segments of the facial nerve analyzed are oligofascicular and polyfascicular, with a number of 3 to 8 fascicules. We conclude that knowledge on the fascicular organization of nerves, particularly the facial nerve, is paramount in surgical procedures using grafts, interfascicular sutures, among other microsurgeries which involve nerve restoration.
