[Intratumoral administration of 5-fluorouracil and bleomycin in inoperable cancer of the cardioesophageal region]. / Vnutriopukholevoe vvedenie 5-ftorouratsila i bleomitsina pri neoperabel'nom rake kardioézofagal'noi oblasti.

The methods and results of combined therapy (drugs+radiation+intratumoral injection of 5-fluorouracil and (chemoimmunotherapy+intratumoral injection of bleomycin) were compared with the standard procedure (chemotherapy+radiation) for treating inoperable cancer in the cardioesophageal region. The study group included 47 patients aged 32-79. Tumors were inoperable due to considerable expansion in 32 and remote metastases in 15 patients. The single dose of 5-fluorouracil injected into tumor via a fibroendoscope at the start of chemoradiation treatment ranged 750-1,000 mg (course dose of the drug-2.75-4.25 g, total focal dose of radiation -24-36 Gy). The single intratumoral dose of bleomycin injected prior to total polychemotherapy (vinblastine, ftorafur, cyclophosphamide) was 10-15 mg. In the control group receiving standard combined therapy, the total focal dose was 60-62 Gy and course dose of 5-fluorouracil -5-7 g. Objective improvement was observed in 63.6% matched by a mean survival time of 14.6 months after combined therapy given in conjunction with supporting chemoimmunotherapy. This showed an improvement on the results of standard combination therapy which were 58.3% and 9.3 months, respectively.

[Measurement of the transmucosal biopotential differential via a fiber endoscope as a means of diagnosing the spread of malignant stomach neoplasms into the serous membrane]. / Izmerenie raznosti transmukoznogo biopotentsiala cherez fibroéndoskop kak sposob diagnostiki prorastaniia zlokachestvennykh novoobrazovanii zheludka v seroznuiu obolochku.

A new time-saving procedure of preoperative diagnosis of involvement of serosa and adjacent organs in gastric cancer is discussed. It is based on the comparison of electric potentials across tumor (A) and normal gastric mucosa (B) measured by means of fibroendoscope. Coefficient K which is an A/B ratio was obtained. Statistically significant differences in coefficient K were established in 86 cases with and without involvement of serosa. Difference of electric potentials across gastric mucosa was measured by a newly-developed device which includes platinum electrodes. The null electrode was implanted subcutaneously, the active one was inserted into the stomach.

[Combined chemoimmunotherapy in stomach cancer and hematosarcoma]. / Kombinirovannaia khimioimmunoterapiia pri rake i gematosarkome zheludka.

A new method was elaborated for the combined chemoimmunotherapy of cancer and hematosarcoma of the stomach by means of intratumoral submucous injection via a fiberoptic endoscope of 5-fluorouracil (or cyclophosphane) followed by general ftorafur chemotherapy (or vincristine, cyclophosphane, 5-fluorouracil) followed by general ftorafur chemotherapy (or vincristine, cyclophosphane, 5-fluorouracil), or by intratumoral submucous injection of zymosane at termination of the chemotherapy course. The material comprising 96 patients, treated by the new method and 52 control patients after general chemotherapy has proved a greater efficacy of the method of combined chemoimmunotherapy, especially in infiltrative-exophytic and perigastric recurrences of cancer of the stomach as well as in radically operated subjects.