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1.
J Cereb Blood Flow Metab ; 33(5): 760-3, 2013 May.
Article in English | MEDLINE | ID: mdl-23403376

ABSTRACT

Hypertension is associated with cerebral small vessel disease (SVD) and with diffuse white matter hyperintensities (WMH) on T2-weighted magnetic resonance imaging (MRI). We tested whether stroke-prone spontaneously hypertensive rats (SHRSP), a model of chronic hypertension, exhibit WMH. Male SHRSP (age 10 months) without stroke symptoms were compared with age-matched male WKY rats. Stroke-prone spontaneously hypertensive rats exhibited no WMH on MRI scans (T2, T2*, diffusion tensor imaging) and no neuropathological lesions. While leptomeningeal arteries exhibited fibrohyaline wall thickening, with decreased smooth muscle actin relative to WKY, deep penetrating arterioles within the caudate nuclei had no vasculopathy. We conclude that WMH are not an obligate feature of stroke-free SHRSP aged up to 10 months.


Subject(s)
Brain/pathology , Hypertension/complications , Leukoencephalopathies/pathology , Stroke/complications , Animals , Brain/blood supply , Cerebral Arteries/pathology , Leukoencephalopathies/complications , Male , Myelin Basic Protein/analysis , Rats , Rats, Inbred SHR
2.
J Neurol Sci ; 322(1-2): 237-40, 2012 Nov 15.
Article in English | MEDLINE | ID: mdl-22698483

ABSTRACT

Small vessel disease (SVD) is a frequent cause of vascular cognitive impairment (VCI), encompassing vascular dementia. SVD is characterised by vasculopathy in deep penetrating arteries, diffuse white matter lesions (seen radiologically as leukoaraiosis) and focal, lacunar infarcts. Risk factors are age and hypertension but the pathogenic mechanism is unknown. Recent systematic reviews assessed experimental models of SVD or VCI. Chronically hypertensive animals (e.g. stroke-prone spontaneously hypertensive rats) display some features of SVD vasculopathy, such as vessel wall thickening. White matter lesions are seen in chronic hypoperfusion states (e.g. carotid occlusion/stenosis models). Small focal infarcts are induced by targeted ischemic challenge (surgical occlusion of a small artery, or stereotaxic endothelin-1 injection). Some degree of cognitive impairment is detectable in most cerebrovascular models, probably reflecting the broad neuroanatomical mapping of cognitive function. Important confounds to be considered in animal models of VCI are somatosensory impairment and hippocampal damage. Advances in clinical understanding will come from targeting specific questions on some aspect of SVD (e.g. vasculopathy, white matter damage) to the appropriate model in vivo. In vivo models of SVD are likely to benefit experimental studies of pathological processes, interactions with other brain disease states (such as Alzheimer disease), and therapeutic strategies.


Subject(s)
Cerebral Small Vessel Diseases , Cognition Disorders/etiology , Cognition Disorders/pathology , Disease Models, Animal , Animals , Cerebral Small Vessel Diseases/complications , Cerebral Small Vessel Diseases/pathology , Cerebral Small Vessel Diseases/therapy , Humans
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