ABSTRACT
This brief communication describes the characterization of a new allele, DRB1*1336.
Subject(s)
HLA-DR Antigens/genetics , HLA-DR Antigens/immunology , Base Sequence , Female , Genetic Variation , HLA-DRB1 Chains , Homozygote , Humans , Leukemia/genetics , Molecular Sequence DataABSTRACT
The cells of the uterine lining (endometrium) may grow, in a aggressive fashion and invade the muscular portion of the uterus. This disorder is nonmalignant but is a serious and disabling disease called adenomyosis. The author presents an actual evaluation of the diagnosis and treatment of adenomyosis with a revision of the world literature, a retrospective evaluation of personal cases that includes a very unusual case of adenomyosis
Subject(s)
Humans , Female , Adult , Endometriosis/diagnosis , Endometriosis/therapyABSTRACT
The cells of the uterine lining (endometrium) may grow, in a aggressive fashion and invade the muscular portion of the uterus. This disorder is nonmalignant but is a serious and disabling disease called adenomyosis. The author presents an actual evaluation of the diagnosis and treatment of adenomyosis with a revision of the world literature, a retrospective evaluation of personal cases that includes a very unusual case of adenomyosis.
Subject(s)
Endometriosis/diagnosis , Endometriosis/therapy , Adult , Female , HumansABSTRACT
This study sought to determine risk factors for genital infection with papillomavirus (HPV) in Panamanian women 20-49 years old. Subjects were randomly selected from Herrera and Panama provinces (cervical cancer incidence 79 and 25/100,000, respectively). Participants were interviewed to determine sexual behavior. Cervicovaginal lavage specimens were obtained to test for HPV DNA by commercial dot blot hybridization. HPV-16/18 DNA was detected significantly more frequently (5%) in Panama than Herrera (2%) samples (P = .002). Clearly, infection with high-risk HPV types alone cannot account for the differences in cervical cancer incidence between the two populations. HPV-16/18 detection decreased with increasing years of sexual experience among all women in Panama and among women with multiple partners in Herrera. However, HPV-16/18 detection did not change with sexual experience among monogamous women in Herrera. Thus, the epidemiology of HPV is complex and reflects both virus- and population-specific factors.
