Gold nanoparticle detection and quantification in therapeutic MV beams via pair production.

PURPOSE: We propose a new detection method of gold nanoparticles (AuNP) in therapeutic megavoltage (MV) x-ray beams by means of coincidence counting of annihilation photons following pair production in gold. METHODS: The proposed MV x-ray induced positron emission (MVIPE) imaging technique is studied by radiation transport computations using MCNP6 (3D) and CEPXS/ONEDANT (1D) codes for two water phantoms: a 35 cm slab and a similarly sized cylinder, both having a 5 cm AuNP filled region in the center. MVIPE is compared to the standard x-ray fluorescence computed tomography (XFCT). MVIPE adopts MV x-ray sources (Co-60, 2 MV, 6 MV, 6 MV with closed MLC and 15 MV) and relies on the detection of 511 keV photon-pairs. XFCT uses kilovoltage sources (100 kVp, 120 kVp and 150 kVp) and imaging is characterized by analysis of k α1,2 Au characteristic lines. Three levels of AuNP concentration were studied: 0.1%, 1% and 10% by weight. RESULTS: Annihilation photons in the MVIPE technique originate both in the AuNP and in water along the x-ray beam path with significantly larger production in the AuNP-loaded region. MVIPE signal from AuNP is linearly increasing with AuNP concentration up to 10%wt, while XFCT signal reaches saturation due to self-absorption within AuNP. The production of annihilation photons is proportional to the MV source energy. MVIPE technique using a 15 MV pencil beam and 10 wt% AuNP detects about 4.5 × 103 511 keV-photons cm-2 at 90° w/r to the incident beam per 109 source photons cm-2; 500 of these come from AuNP. In contrast, the XFCT technique using 150 kVp detects only about 100 k α1-photons cm-2 per 109 source photons cm-2. CONCLUSIONS: In MVIPE, the number of annihilation photons produced for different MV-beam energies and AuNP concentrations is significantly greater than the k α1 photons generated in XFCT. Coincidence counting in MVIPE allows to avoid collimation, which is a major limiting factor in XFCT. MVIPE challenges include the filtering of Compton scatter and annihilation photons originating in water.

A Monte Carlo study of I-125 prostate brachytherapy with gold nanoparticles: dose enhancement with simultaneous rectal dose sparing via radiation shielding.

We investigate via Monte Carlo simulations a new 125I brachytherapy treatment technique for high-risk prostate cancer patients via injection of Au nanoparticle (AuNP) directly into the prostate. The purpose of using the nanoparticles is to increase the therapeutic index via two synergistic effects: enhanced energy deposition within the prostate and simultaneous shielding of organs at risk from radiation escaping from the prostate. Both uniform and non-uniform concentrations of AuNP are studied. The latter are modeled considering the possibility of AuNP diffusion after the injection using brachy needles. We study two extreme cases of coaxial AuNP concentrations: centered on brachy needles and centered half-way between them. Assuming uniform distribution of 30 mg g-1 of AuNP within the prostate, we obtain a dose enhancement larger than a factor of 2 to the prostate. Non-uniform concentration of AuNP ranging from 10 mg g-1 and 66 mg g-1 were studied. The higher the concentration in a given region of the prostate the greater is the enhancement therein. We obtain the highest dose enhancement when the brachytherapy needles are coincident with AuNP injection needles but, at the same time, the regions in the tail are colder (average dose ratio of 0.7). The best enhancement uniformity is obtained with the seeds in the tail of the AuNP distribution. In both uniform and non-uniform cases the urethra and rectum receive less than 1/3 dose compared to an analog treatment without AuNP. Remarkably, employing AuNP not only significantly increases dose to the target but also decreases dose to the neighboring rectum and even urethra, which is embedded within the prostate. These are mutually interdependent effects as more enhancement leads to more shielding and vice-versa. Caution must be paid since cold spot or hot spots may be created if the AuNP concentration versus seed position is not properly distributed respect to the seed locations.

Comment on: Polarity effects and apparent ion recombination in microionization chambers Med. Phys. 43(5), 2141-2152 (2016).

In a recent paper of Miller et al. (Med. Phys. 43(5), 2141-2152 (2016), the voltage dependence polarity effect of microionization chambers was studied. It was identified that polarity effect arises from the difference in electric potential between the collecting electrode and the guard electrode, which in turn deforms the electric field and affects the charge collection. Nevertheless, the cause of such potential difference has not been identified. In this letter, we explain that the electric potential perturbation arises from the work function difference of the disparate materials electrodes (collecting vs guard electrodes in the particular case).

Kilovoltage radiosurgery with gold nanoparticles for neovascular age-related macular degeneration (AMD): a Monte Carlo evaluation.

This work uses Monte Carlo radiation transport simulation to assess the potential benefits of gold nanoparticles (AuNP) in the treatment of neovascular age-related macular degeneration with stereotactic radiosurgery. Clinically, a 100 kVp x-ray beam of 4 mm diameter is aimed at the macula to deliver an ablative dose in a single fraction. In the transport model, AuNP accumulated at the bottom of the macula are targeted with a source representative of the clinical beam in order to provide enhanced dose to the diseased macular endothelial cells. It is observed that, because of the AuNP, the dose to the endothelial cells can be significantly enhanced, allowing for greater sparing of optic nerve, retina and other neighboring healthy tissue. For 20 nm diameter AuNP concentration of 32 mg g(-1), which has been shown to be achievable in vivo, a dose enhancement ratio (DER) of 1.97 was found to be possible, which could potentially be increased through appropriate optimization of beam quality and/or AuNP targeting. A significant enhancement in dose is seen in the vicinity of the AuNP layer within 30 µm, peaked at the AuNP-tissue interface. Different angular tilting of the 4 mm beam results in a similar enhancement. The DER inside and in the penumbra of the 4 mm irradiation-field are almost the same while the actual delivered dose is more than one order of magnitude lower outside the field leading to normal tissue sparing. The prescribed dose to macular endothelial cells can be delivered using almost half of the radiation allowing reduction of dose to the neighboring organs such as retina/optic nerve by 49% when compared to a treatment without AuNP.