ABSTRACT
To our knowledge, only two cases of pancreatic involvement after tricyclic overdose have so far been described in the literature. We report another case of pancreatic involvement after tricyclic antidepressant overdose. Patient. A 30-year-old female was admitted to our Emergency Room after having ingested 800 mg of amitriptyline in a suicide attempt. On the second day of hospitalization, high serum values of amylase 823 IU/l (normal values < 220 IU/l) and lipase 1054 IU/l (normal value < 270 IU/l) were found. The pancreas appeared normal upon ultrasonography. Serum pancreatic enzymes further increased on the third day of hospitalization, peaked on the fourth day and then progressively decreased. Repeated ultrasonography examination did not show any alteration in the pancreatic gland. The patient was discharged eight days after admission. Fifteen days after the overdose episode, the ultrasonographic examination still did not show any alteration of the pancreatic gland, and serum amylase and lipase were 403 IU/l and 239 IU/l, respectively. In our opinion, serum pancreatic enzymes should be determined in patients with tricyclic overdose in order to detect possible pancreatic involvement.
Subject(s)
Amitriptyline/poisoning , Antidepressive Agents, Tricyclic/poisoning , Pancreatitis/chemically induced , Adult , Amylases/blood , Drug Overdose , Female , Humans , Lipase/blood , Pancreas/diagnostic imaging , Pancreatitis/enzymology , Suicide, Attempted , UltrasonographyABSTRACT
We report the case of a young man suffering from epilepsy who developed chronic calcified pancreatitis after ten years of therapy with the anticonvulsant drugs carbamazepine and phenytoin. Long-term anticonvulsant drug therapy may have a contributory role in the development of chronic pancreatitis by chronic stimulation of cytochromes P-450.
Subject(s)
Anticonvulsants/adverse effects , Pancreatitis/chemically induced , Adult , Carbamazepine/adverse effects , Chronic Disease , Cytochrome P-450 Enzyme System/metabolism , Epilepsy/drug therapy , Epilepsy/metabolism , Free Radicals/metabolism , Humans , Male , Phenytoin/adverse effects , Valproic Acid/adverse effectsABSTRACT
A rare case of exocrine pancreatic damage in a patient with Wegener's granulomatosis is reported. The pancreatic amino acid consumption test, a new tubeless technique, revealed exocrine pancreatic insufficiency before and after immunosuppressive therapy. The presence of exocrine pancreatic insufficiency in this patient raises the possibility of pancreatic involvement in Wegener's granulomatosis.
Subject(s)
Exocrine Pancreatic Insufficiency/complications , Granulomatosis with Polyangiitis/complications , Aged , Amino Acids/blood , Exocrine Pancreatic Insufficiency/diagnosis , Exocrine Pancreatic Insufficiency/pathology , Granulomatosis with Polyangiitis/pathology , Humans , Male , Pancreas/pathology , Pancreatic Function TestsABSTRACT
20-40 Mg per day of gangliosides in association with the therapy already in use were given to patients suffering from acute cerebreal vascular lesions. The results reported in the present work refer to the time necessary for the return to normal functionality. It was observed that such parameter is practically half of that occuring in non-treated subjects. Therefore, the therapeutic usefulness of such glycolipids for the return to normal of the motor functionality and also of the coscience conditions of patients suffering from acute vascular CNS lesions is underlined.
