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Bioorg Med Chem Lett
; 21(16): 4891-9, 2011 Aug 15.
Article
in English
| MEDLINE
| ID: mdl-21757343
ABSTRACT
A series of 6-aryl-3-pyrrolidinylpyridine analogs was explored as structurally novel negative allosteric modulators of the mGlu5 receptor lacking an alkyne or oxadiazole moiety. Compounds in this series were characterized by tractable SAR, good in vitro potencies and brain penetration in rodents.
