ABSTRACT
Identification of the type of human papilloma virus (HPV) was done by means of polymerase chain reaction in 40 children with juvenile respiratory papillomatosis (JRP). Adjuvant to surgery interferon treatment was carried out in 18 patients (study group) with severe JRP. The rest 22 patients (control group) with less severe papillomatosis received only surgical treatment. The majority of the patients from both the groups had the virus type 6/11 (72.2 and 77.3% for the study and control groups, respectively). The assessment of a relationship between HPV type and effectiveness of interferon treatment in the study group has shown that the share of patients with effective and uneffective interferon therapy in each category (by HPV type) was about the same, i.e. no correlation exists between HPV type and interferon therapy effectiveness.
Subject(s)
Interferon Type I/therapeutic use , Laryngeal Neoplasms/drug therapy , Papilloma/drug therapy , Papillomaviridae/classification , Papillomavirus Infections/drug therapy , Tumor Virus Infections/drug therapy , Adolescent , Child , Child, Preschool , Drug Administration Routes , Drug Therapy, Combination , Female , Humans , Infant , Interferon Type I/administration & dosage , Interferon alpha-2 , Interferon-alpha , Laryngeal Neoplasms/pathology , Laryngeal Neoplasms/virology , Male , Neoplasm Recurrence, Local , Papilloma/pathology , Papilloma/virology , Papillomavirus Infections/pathology , Papillomavirus Infections/virology , RNA, Viral/analysis , Recombinant Proteins , Treatment Outcome , Tumor Virus Infections/pathology , Tumor Virus Infections/virologySubject(s)
Chlamydia trachomatis/isolation & purification , Genital Diseases, Female/microbiology , Genital Diseases, Male/microbiology , Mycoplasma/isolation & purification , Ureaplasma/isolation & purification , Base Sequence , Chlamydia trachomatis/genetics , DNA Primers , Female , Female Urogenital Diseases/microbiology , Humans , Male , Male Urogenital Diseases , Molecular Sequence Data , Mycoplasma/genetics , Polymerase Chain Reaction , Seasons , Ureaplasma/geneticsSubject(s)
Chlamydia trachomatis/isolation & purification , Mycoplasma/isolation & purification , Ureaplasma urealyticum/isolation & purification , Base Sequence , Cervix Uteri/microbiology , Chlamydia trachomatis/genetics , DNA Primers , Female , Humans , Molecular Sequence Data , Mycoplasma/genetics , Polymerase Chain Reaction , Ureaplasma urealyticum/genetics , Ureter/microbiologyABSTRACT
A. personal computer-based information system meeting the requirements of the RF Ministry of Health on mass fluorographic examinations is proposed for introduction in wide practice. The system provides significant and complete data on the population subject to preventive check-ups, raises the efficacy of the latter, makes automatic planning.
